Cargando…

28-Day Oral Chronic Toxicity Study of Arctigenin in Rats

Arctium lappa (burdock) is the most popular daily edible vegetable in China and Japan because of its general health tonic effects. Previous studies focused on the beneficial role of Arctigenin but neglected its potential side-effects and toxicities. In the present study, the sub-chronic toxicity pro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tan, Yu-jun, Ren, Yu-shan, Gao, Lei, Li, Lan-fang, Cui, Li-juan, Li, Bin, Li, Xin, Yang, Jian, Wang, Ming-zhi, Lv, Yuan-yuan, Xu, Xiao-li, Yao, Jing-chun, Liu, Zhong, Zhang, Gui-min, Li, Jie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169246/ https://www.ncbi.nlm.nih.gov/pubmed/30319414 http://dx.doi.org/10.3389/fphar.2018.01077

Ejemplares similares

Toxicity Study of 28-Day Subcutaneous Injection of Arctigenin in Beagle Dogs
por: Li, Jie, et al.
Publicado: (2019)

Elucidation of Arctigenin Pharmacokinetics and Tissue Distribution after Intravenous, Oral, Hypodermic and Sublingual Administration in Rats and Beagle Dogs: Integration of In Vitro and In Vivo Findings
por: Li, Jie, et al.
Publicado: (2017)

Arctigenin Inhibits Liver Cancer Tumorigenesis by Inhibiting Gankyrin Expression via C/EBPα and PPARα
por: Sun, Ying, et al.
Publicado: (2018)

Serial five-membered lactone ring ions in the treatment of Alzheimer’s diseases-comprehensive profiling of arctigenin metabolites and network analysis
por: Li, Yanan, et al.
Publicado: (2022)

Arctigenin Treatment Protects against Brain Damage through an Anti-Inflammatory and Anti-Apoptotic Mechanism after Needle Insertion
por: Song, Jie, et al.
Publicado: (2016)

Acute toxicity and repeated dose 28-day oral toxicity study of metriviv syrup in female rats
por: Patel, Amit G., et al.
Publicado: (2018)

Toxicological Assessment of Bromochlorophene: Single and Repeated-Dose 28-Day Oral Toxicity, Genotoxicity, and Dermal Application in Sprague–Dawley Rats
por: Won, Hansol, et al.
Publicado: (2021)

Arctigenin Induces an Activation Response in Porcine Alveolar Macrophage Through TLR6-NOX2-MAPKs Signaling Pathway
por: Lu, Zheng, et al.
Publicado: (2018)

Pharmacokinetics of Arctigenin and Fructus Arctii Powder in Piglets
por: He, Bin, et al.
Publicado: (2019)

Toxicity evaluation induced by single and 28-days repeated exposure of withametelin and daturaolone in Sprague Dawley rats
por: Baig, Muhammad Waleed, et al.
Publicado: (2022)

Acute and subacute oral toxicity assessment of Gancao Xiexin decoction in Sprague-Dawley rats
por: Ru, Li, et al.
Publicado: (2023)

AMPK/SIRT1 Pathway is Involved in Arctigenin-Mediated Protective Effects Against Myocardial Ischemia-Reperfusion Injury
por: Liu, Cheng-Yin, et al.
Publicado: (2021)

Arctigenin: a lignan from Arctium lappa
por: Gao, Haiyan, et al.
Publicado: (2008)

Arctigenin Attenuates Tumor Metastasis Through Inhibiting Epithelial–Mesenchymal Transition in Hepatocellular Carcinoma via Suppressing GSK3β-Dependent Wnt/β-Catenin Signaling Pathway In Vivo and In Vitro
por: Lu, Zheng, et al.
Publicado: (2019)

Arctigenin Exerts Neuroprotective Effect by Ameliorating Cortical Activities in Experimental Autoimmune Encephalomyelitis In Vivo
por: Wei, Liangpeng, et al.
Publicado: (2021)

Toxic Constituents Index: A Toxicity-Calibrated Quantitative Evaluation Approach for the Precise Toxicity Prediction of the Hypertoxic Phytomedicine—Aconite
por: Zhang, Ding-kun, et al.
Publicado: (2016)

Biodistribution of arctigenin-loaded nanoparticles designed for multimodal imaging
por: Cui, Qingxin, et al.
Publicado: (2017)

Arctigenin Reduces Myofibroblast Activities in Oral Submucous Fibrosis by LINC00974 Inhibition
por: Lin, Ching-Yeh, et al.
Publicado: (2019)

28-Day Oral Toxicity of Cadmium Selenide in Sprague-Dawley Rats
por: Kim, Yong Soon, et al.
Publicado: (2009)

Arctigenin hinders the invasion and metastasis of cervical cancer cells via the FAK/paxillin pathway
por: Liao, Dan, et al.
Publicado: (2023)

Genotoxicity and 28-day repeated dose oral toxicity study of ovatodiolide in rats
por: Chen, Jing-Chun, et al.
Publicado: (2021)

Efficacy and Safety of Shenqu Xiaoshi Oral Liquid Compared With Domperidone Syrup in Children With Functional Dyspepsia
por: Yu, Yi, et al.
Publicado: (2022)

Arctigenin protects mice from thioglycollate‐induced acute peritonitis
por: Zhao, Jingyi, et al.
Publicado: (2020)

In vitro genotoxicity assessment and 28-day repeated dose oral toxicity study of steady-calcium formula in rats
por: Chang, Ting-Yu, et al.
Publicado: (2022)

Corrigendum: Efficacy and Safety of Shenqu Xiaoshi Oral Liquid Compared With Domperidone Syrup in Children With Functional Dyspepsia
por: Yu, Yi, et al.
Publicado: (2022)

Pharmacology, Toxicity, Bioavailability, and Formulation of Magnolol: An Update
por: Lin, Yiping, et al.
Publicado: (2021)

The Mechanism by Which Dodecyl Dimethyl Benzyl Ammonium Chloride Increased the Toxicity of Chlorpyrifos to Spodoptera exigua
por: Cui, Li, et al.
Publicado: (2017)

Optimisation of the Conversion and Extraction of Arctigenin From Fructus arctii Into Arctiin Using Fungi
por: Lu, Zheng, et al.
Publicado: (2021)

Ninety days repeated dose oral toxicity study of Makaradhwaja in Wistar rats
por: Jamadagni, Shrirang, et al.
Publicado: (2017)

Sub-Acute Oral Toxicity of a Novel Derivative of Agomelatine in Rats in a Sex-Dependent Manner
por: Yang, Qiushi, et al.
Publicado: (2019)

Acute and 28-Day Subchronic Oral Toxicity of an Ethanol Extract of Zingiber zerumbet (L.) Smith in Rodents
por: Chang, Chia Ju, et al.
Publicado: (2012)

Arctigenin: pharmacology, total synthesis, and progress in structure modification
por: Wu, Dan, et al.
Publicado: (2022)

Hypertensive Rats Treated Chronically With N(ω)-Nitro-L-Arginine Methyl Ester (L-NAME) Induced Disorder of Hepatic Fatty Acid Metabolism and Intestinal Pathophysiology
por: Li, Bo, et al.
Publicado: (2020)

Arctigenin Efficiently Enhanced Sedentary Mice Treadmill Endurance
por: Tang, Xuan, et al.
Publicado: (2011)

Evaluation on the antiviral activity of arctigenin against spring viraemia of carp virus
por: Shen, Yu-Feng, et al.
Publicado: (2018)

Identification of phosphodiesterase-4 as the therapeutic target of arctigenin in alleviating psoriatic skin inflammation
por: Li, Heng, et al.
Publicado: (2021)

Oral toxicity of titanium dioxide P25 at repeated dose 28-day and 90-day in rats
por: Heo, Min Beom, et al.
Publicado: (2020)

Investigating the Pharmacological Mechanisms of SheXiang XinTongNing Against Coronary Heart Disease Based on Network Pharmacology and Experimental Evaluation
por: Jia, Li-ying, et al.
Publicado: (2021)

Gut Microbiota Combined With Metabolomics Reveals the Repeated Dose Oral Toxicity of β-Cyclodextrin in Mice
por: Lv, Shuangyu, et al.
Publicado: (2021)

Genotoxicity and 28-day repeated dose oral toxicity study of garlic essential oil in mice
por: Lin, Yu-En, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_n0bq9udhv8i01v5s6fnde5dg96