Null Mutation of the Fascin2 Gene by TALEN Leading to Progressive Hearing Loss and Retinal Degeneration in C57BL/6J Mice

Fascin2 (FSCN2) is an actin cross-linking protein that is mainly localized in retinas and in the stereocilia of hair cells. Earlier studies showed that a deletion mutation in human FASCIN2 (FSCN2) gene could cause autosomal dominant retinitis pigmentosa. Recent studies have indicated that a missense...

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Detalles Bibliográficos
Autores principales: Liu, Xiang, Zhao, Mengmeng, Xie, Yi, Li, Ping, Wang, Oumei, Zhou, Bingxin, Yang, Linlin, Nie, Yao, Cheng, Lin, Song, Xicheng, Jin, Changzhu, Han, Fengchan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2018
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169377/
https://www.ncbi.nlm.nih.gov/pubmed/30082328
http://dx.doi.org/10.1534/g3.118.200405

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