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Stress peptides sensitize fear circuitry to promote passive coping
Survival relies on optimizing behavioral responses through experience. Animals often react to acute stress by switching to passive behavioral responses when coping with environmental challenge. Despite recent advances in dissecting mammalian circuitry for Pavlovian fear, the neuronal basis underlyin...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169733/ https://www.ncbi.nlm.nih.gov/pubmed/29904149 http://dx.doi.org/10.1038/s41380-018-0089-2 |
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author | Pliota, Pinelopi Böhm, Vincent Grössl, Florian Griessner, Johannes Valenti, Ornella Kraitsy, Klaus Kaczanowska, Joanna Pasieka, Manuel Lendl, Thomas Deussing, Jan M. Haubensak, Wulf |
author_facet | Pliota, Pinelopi Böhm, Vincent Grössl, Florian Griessner, Johannes Valenti, Ornella Kraitsy, Klaus Kaczanowska, Joanna Pasieka, Manuel Lendl, Thomas Deussing, Jan M. Haubensak, Wulf |
author_sort | Pliota, Pinelopi |
collection | PubMed |
description | Survival relies on optimizing behavioral responses through experience. Animals often react to acute stress by switching to passive behavioral responses when coping with environmental challenge. Despite recent advances in dissecting mammalian circuitry for Pavlovian fear, the neuronal basis underlying this form of non-Pavlovian anxiety-related behavioral plasticity remains poorly understood. Here, we report that aversive experience recruits the posterior paraventricular thalamus (PVT) and corticotropin-releasing hormone (CRH) and sensitizes a Pavlovian fear circuit to promote passive responding. Site-specific lesions and optogenetic manipulations reveal that PVT-to-central amygdala (CE) projections activate anxiogenic neuronal populations in the CE that release local CRH in response to acute stress. CRH potentiates basolateral (BLA)-CE connectivity and antagonizes inhibitory gating of CE output, a mechanism linked to Pavlovian fear, to facilitate the switch from active to passive behavior. Thus, PVT-amygdala fear circuitry uses inhibitory gating in the CE as a shared dynamic motif, but relies on different cellular mechanisms (postsynaptic long-term potentiation vs. presynaptic facilitation), to multiplex active/passive response bias in Pavlovian and non-Pavlovian behavioral plasticity. These results establish a framework promoting stress-induced passive responding, which might contribute to passive emotional coping seen in human fear- and anxiety-related disorders. |
format | Online Article Text |
id | pubmed-6169733 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-61697332018-12-14 Stress peptides sensitize fear circuitry to promote passive coping Pliota, Pinelopi Böhm, Vincent Grössl, Florian Griessner, Johannes Valenti, Ornella Kraitsy, Klaus Kaczanowska, Joanna Pasieka, Manuel Lendl, Thomas Deussing, Jan M. Haubensak, Wulf Mol Psychiatry Article Survival relies on optimizing behavioral responses through experience. Animals often react to acute stress by switching to passive behavioral responses when coping with environmental challenge. Despite recent advances in dissecting mammalian circuitry for Pavlovian fear, the neuronal basis underlying this form of non-Pavlovian anxiety-related behavioral plasticity remains poorly understood. Here, we report that aversive experience recruits the posterior paraventricular thalamus (PVT) and corticotropin-releasing hormone (CRH) and sensitizes a Pavlovian fear circuit to promote passive responding. Site-specific lesions and optogenetic manipulations reveal that PVT-to-central amygdala (CE) projections activate anxiogenic neuronal populations in the CE that release local CRH in response to acute stress. CRH potentiates basolateral (BLA)-CE connectivity and antagonizes inhibitory gating of CE output, a mechanism linked to Pavlovian fear, to facilitate the switch from active to passive behavior. Thus, PVT-amygdala fear circuitry uses inhibitory gating in the CE as a shared dynamic motif, but relies on different cellular mechanisms (postsynaptic long-term potentiation vs. presynaptic facilitation), to multiplex active/passive response bias in Pavlovian and non-Pavlovian behavioral plasticity. These results establish a framework promoting stress-induced passive responding, which might contribute to passive emotional coping seen in human fear- and anxiety-related disorders. Nature Publishing Group UK 2018-06-14 2020 /pmc/articles/PMC6169733/ /pubmed/29904149 http://dx.doi.org/10.1038/s41380-018-0089-2 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Pliota, Pinelopi Böhm, Vincent Grössl, Florian Griessner, Johannes Valenti, Ornella Kraitsy, Klaus Kaczanowska, Joanna Pasieka, Manuel Lendl, Thomas Deussing, Jan M. Haubensak, Wulf Stress peptides sensitize fear circuitry to promote passive coping |
title | Stress peptides sensitize fear circuitry to promote passive coping |
title_full | Stress peptides sensitize fear circuitry to promote passive coping |
title_fullStr | Stress peptides sensitize fear circuitry to promote passive coping |
title_full_unstemmed | Stress peptides sensitize fear circuitry to promote passive coping |
title_short | Stress peptides sensitize fear circuitry to promote passive coping |
title_sort | stress peptides sensitize fear circuitry to promote passive coping |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169733/ https://www.ncbi.nlm.nih.gov/pubmed/29904149 http://dx.doi.org/10.1038/s41380-018-0089-2 |
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