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Drug-susceptible tuberculosis treatment success and associated factors in Ethiopia from 2005 to 2017: a systematic review and meta-analysis

OBJECTIVES: The main aim of this study was to assess the overall tuberculosis (TB) treatment success in Ethiopia and to identify potential factors for poor TB treatment outcome. DESIGN: A systematic review and meta-analysis of published literature was conducted. Original studies were identified thro...

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Autores principales: Seid, Mohammed Assen, Ayalew, Mohammed Biset, Muche, Esileman Abdela, Gebreyohannes, Eyob Alemayehu, Abegaz, Tadesse Melaku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169771/
https://www.ncbi.nlm.nih.gov/pubmed/30257846
http://dx.doi.org/10.1136/bmjopen-2018-022111
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author Seid, Mohammed Assen
Ayalew, Mohammed Biset
Muche, Esileman Abdela
Gebreyohannes, Eyob Alemayehu
Abegaz, Tadesse Melaku
author_facet Seid, Mohammed Assen
Ayalew, Mohammed Biset
Muche, Esileman Abdela
Gebreyohannes, Eyob Alemayehu
Abegaz, Tadesse Melaku
author_sort Seid, Mohammed Assen
collection PubMed
description OBJECTIVES: The main aim of this study was to assess the overall tuberculosis (TB) treatment success in Ethiopia and to identify potential factors for poor TB treatment outcome. DESIGN: A systematic review and meta-analysis of published literature was conducted. Original studies were identified through a computerised systematic search using PubMed, Google Scholar and Science Direct databases. Heterogeneity across studies was assessed using Cochran’s Q test and I(2) statistic. Pooled estimates of treatment success were computed using the random-effects model with 95% CI using Stata V.14 software. RESULTS: A total of 230 articles were identified in the systematic search. Of these 34 observational studies were eligible for systematic review and meta-analysis. It was found that 117 750 patients reported treatment outcomes. Treatment outcomes were assessed by World Health Organization (WHO) standard definitions of TB treatment outcome. The overall pooled TB treatment success rate in Ethiopia was 86% (with 95% CI 83%_88%). TB treatment success rate for each region showed that, Addis Ababa (93%), Oromia (84%), Amhara (86%), Southern Nations (83%), Tigray (85%) and Afar (86%). Mainly old age, HIV co-infection, retreatment cases and rural residence were the most frequently identified factors associated with poor TB treatment outcome. CONCLUSION: The result of this study revealed that the overall TB treatment success rate in Ethiopia was below the threshold suggested by WHO (90%). There was also a discrepancy in TB treatment success rate among different regions of Ethiopia. In addition to these, HIV co-infection, older age, retreatment cases and rural residence were associated with poor treatment outcome. In order to further improve the treatment success rate, it is strategic to give special consideration for regions which had low TB treatment success and patients with TB with HIV co-infection, older age, rural residence and retreatment cases.
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spelling pubmed-61697712018-10-05 Drug-susceptible tuberculosis treatment success and associated factors in Ethiopia from 2005 to 2017: a systematic review and meta-analysis Seid, Mohammed Assen Ayalew, Mohammed Biset Muche, Esileman Abdela Gebreyohannes, Eyob Alemayehu Abegaz, Tadesse Melaku BMJ Open Infectious Diseases OBJECTIVES: The main aim of this study was to assess the overall tuberculosis (TB) treatment success in Ethiopia and to identify potential factors for poor TB treatment outcome. DESIGN: A systematic review and meta-analysis of published literature was conducted. Original studies were identified through a computerised systematic search using PubMed, Google Scholar and Science Direct databases. Heterogeneity across studies was assessed using Cochran’s Q test and I(2) statistic. Pooled estimates of treatment success were computed using the random-effects model with 95% CI using Stata V.14 software. RESULTS: A total of 230 articles were identified in the systematic search. Of these 34 observational studies were eligible for systematic review and meta-analysis. It was found that 117 750 patients reported treatment outcomes. Treatment outcomes were assessed by World Health Organization (WHO) standard definitions of TB treatment outcome. The overall pooled TB treatment success rate in Ethiopia was 86% (with 95% CI 83%_88%). TB treatment success rate for each region showed that, Addis Ababa (93%), Oromia (84%), Amhara (86%), Southern Nations (83%), Tigray (85%) and Afar (86%). Mainly old age, HIV co-infection, retreatment cases and rural residence were the most frequently identified factors associated with poor TB treatment outcome. CONCLUSION: The result of this study revealed that the overall TB treatment success rate in Ethiopia was below the threshold suggested by WHO (90%). There was also a discrepancy in TB treatment success rate among different regions of Ethiopia. In addition to these, HIV co-infection, older age, retreatment cases and rural residence were associated with poor treatment outcome. In order to further improve the treatment success rate, it is strategic to give special consideration for regions which had low TB treatment success and patients with TB with HIV co-infection, older age, rural residence and retreatment cases. BMJ Publishing Group 2018-09-25 /pmc/articles/PMC6169771/ /pubmed/30257846 http://dx.doi.org/10.1136/bmjopen-2018-022111 Text en © Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Infectious Diseases
Seid, Mohammed Assen
Ayalew, Mohammed Biset
Muche, Esileman Abdela
Gebreyohannes, Eyob Alemayehu
Abegaz, Tadesse Melaku
Drug-susceptible tuberculosis treatment success and associated factors in Ethiopia from 2005 to 2017: a systematic review and meta-analysis
title Drug-susceptible tuberculosis treatment success and associated factors in Ethiopia from 2005 to 2017: a systematic review and meta-analysis
title_full Drug-susceptible tuberculosis treatment success and associated factors in Ethiopia from 2005 to 2017: a systematic review and meta-analysis
title_fullStr Drug-susceptible tuberculosis treatment success and associated factors in Ethiopia from 2005 to 2017: a systematic review and meta-analysis
title_full_unstemmed Drug-susceptible tuberculosis treatment success and associated factors in Ethiopia from 2005 to 2017: a systematic review and meta-analysis
title_short Drug-susceptible tuberculosis treatment success and associated factors in Ethiopia from 2005 to 2017: a systematic review and meta-analysis
title_sort drug-susceptible tuberculosis treatment success and associated factors in ethiopia from 2005 to 2017: a systematic review and meta-analysis
topic Infectious Diseases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169771/
https://www.ncbi.nlm.nih.gov/pubmed/30257846
http://dx.doi.org/10.1136/bmjopen-2018-022111
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