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A massively parallel reporter assay reveals context-dependent activity of homeodomain binding sites in vivo

Cone-rod homeobox (CRX) is a paired-like homeodomain transcription factor (TF) and a master regulator of photoreceptor development in vertebrates. The in vitro DNA binding preferences of CRX have been described in detail, but the degree to which in vitro binding affinity is correlated with in vivo e...

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Detalles Bibliográficos
Autores principales:	Hughes, Andrew E.O., Myers, Connie A., Corbo, Joseph C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169884/ https://www.ncbi.nlm.nih.gov/pubmed/30158147 http://dx.doi.org/10.1101/gr.231886.117

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