Pioneering, chromatin remodeling, and epigenetic constraint in early T-cell gene regulation by SPI1 (PU.1)

SPI1 (also known as PU.1) is a dominant but transient regulator in early T-cell precursors and a potent transcriptional controller of developmentally important pro-T-cell genes. Before T-lineage commitment, open chromatin is frequently occupied by PU.1, and many PU.1 sites lose accessibility when PU...

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Detalles Bibliográficos
Autores principales: Ungerbäck, Jonas, Hosokawa, Hiroyuki, Wang, Xun, Strid, Tobias, Williams, Brian A., Sigvardsson, Mikael, Rothenberg, Ellen V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169891/
https://www.ncbi.nlm.nih.gov/pubmed/30171019
http://dx.doi.org/10.1101/gr.231423.117

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