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Structures reveal opening of the store-operated calcium channel Orai
The store-operated calcium (Ca(2+)) channel Orai governs Ca(2+) influx through the plasma membrane of many non-excitable cells in metazoans. The channel opens in response to the depletion of Ca(2+) stored in the endoplasmic reticulum (ER). Loss- and gain-of-function mutants of Orai cause disease. Ou...
Autores principales: | Hou, Xiaowei, Burstein, Shana R, Long, Stephen Barstow |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170153/ https://www.ncbi.nlm.nih.gov/pubmed/30160233 http://dx.doi.org/10.7554/eLife.36758 |
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