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Therapeutic activity of sour orange albedo extract and abundant flavanones loaded silica nanoparticles against acrylamide-induced hepatotoxicity

The current research aims to demonstrate the therapeutic effect of sour orange albedo extract (SOAE) and two flavanones loaded-tetraethylorthosilicate (TEOS) using sol-gel technique, in adose100 mg/kg body weight taken orally or45 days against acrylamide (ACR)toxicity in rats. This was achieved thro...

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Autores principales: Rizk, M.Z., Abo-El-matty, D.M., Aly, H.F., Abd-Alla, H.I., Saleh, S.M., Younis, E.A., Elnahrawy, A.M., Haroun, A.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170219/
https://www.ncbi.nlm.nih.gov/pubmed/30294554
http://dx.doi.org/10.1016/j.toxrep.2018.08.021
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author Rizk, M.Z.
Abo-El-matty, D.M.
Aly, H.F.
Abd-Alla, H.I.
Saleh, S.M.
Younis, E.A.
Elnahrawy, A.M.
Haroun, A.A.
author_facet Rizk, M.Z.
Abo-El-matty, D.M.
Aly, H.F.
Abd-Alla, H.I.
Saleh, S.M.
Younis, E.A.
Elnahrawy, A.M.
Haroun, A.A.
author_sort Rizk, M.Z.
collection PubMed
description The current research aims to demonstrate the therapeutic effect of sour orange albedo extract (SOAE) and two flavanones loaded-tetraethylorthosilicate (TEOS) using sol-gel technique, in adose100 mg/kg body weight taken orally or45 days against acrylamide (ACR)toxicity in rats. This was achieved through measuring the activities of specific biochemical parameters related to liver functions in tissue of ACR intoxicated rats as compared to normal one. Liver functions included alanine and aspartate aminotransferases, antioxidants and oxidative stress biomarkers; superoxide dismutase, catalase, glutathione and lipid peroxide (malondialdehyde, MDA). Moreover, histological examination of liver was performed to confirm the biochemical findings. The present results clearly indicated disturbances in all biochemical parameters, such as increase in the liver function enzyme activities and MDA level. Results of ATPase enzyme activities revealed significant decrease in ACR intoxicated rats and liver biomarker enzymes declared significant decrease. On the other hand, treatment of intoxicated rats with the previous different nano-particles natural product demonstrated improvement in all biochemical parameters under investigation.
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spelling pubmed-61702192018-10-05 Therapeutic activity of sour orange albedo extract and abundant flavanones loaded silica nanoparticles against acrylamide-induced hepatotoxicity Rizk, M.Z. Abo-El-matty, D.M. Aly, H.F. Abd-Alla, H.I. Saleh, S.M. Younis, E.A. Elnahrawy, A.M. Haroun, A.A. Toxicol Rep Article The current research aims to demonstrate the therapeutic effect of sour orange albedo extract (SOAE) and two flavanones loaded-tetraethylorthosilicate (TEOS) using sol-gel technique, in adose100 mg/kg body weight taken orally or45 days against acrylamide (ACR)toxicity in rats. This was achieved through measuring the activities of specific biochemical parameters related to liver functions in tissue of ACR intoxicated rats as compared to normal one. Liver functions included alanine and aspartate aminotransferases, antioxidants and oxidative stress biomarkers; superoxide dismutase, catalase, glutathione and lipid peroxide (malondialdehyde, MDA). Moreover, histological examination of liver was performed to confirm the biochemical findings. The present results clearly indicated disturbances in all biochemical parameters, such as increase in the liver function enzyme activities and MDA level. Results of ATPase enzyme activities revealed significant decrease in ACR intoxicated rats and liver biomarker enzymes declared significant decrease. On the other hand, treatment of intoxicated rats with the previous different nano-particles natural product demonstrated improvement in all biochemical parameters under investigation. Elsevier 2018-09-09 /pmc/articles/PMC6170219/ /pubmed/30294554 http://dx.doi.org/10.1016/j.toxrep.2018.08.021 Text en © 2018 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Rizk, M.Z.
Abo-El-matty, D.M.
Aly, H.F.
Abd-Alla, H.I.
Saleh, S.M.
Younis, E.A.
Elnahrawy, A.M.
Haroun, A.A.
Therapeutic activity of sour orange albedo extract and abundant flavanones loaded silica nanoparticles against acrylamide-induced hepatotoxicity
title Therapeutic activity of sour orange albedo extract and abundant flavanones loaded silica nanoparticles against acrylamide-induced hepatotoxicity
title_full Therapeutic activity of sour orange albedo extract and abundant flavanones loaded silica nanoparticles against acrylamide-induced hepatotoxicity
title_fullStr Therapeutic activity of sour orange albedo extract and abundant flavanones loaded silica nanoparticles against acrylamide-induced hepatotoxicity
title_full_unstemmed Therapeutic activity of sour orange albedo extract and abundant flavanones loaded silica nanoparticles against acrylamide-induced hepatotoxicity
title_short Therapeutic activity of sour orange albedo extract and abundant flavanones loaded silica nanoparticles against acrylamide-induced hepatotoxicity
title_sort therapeutic activity of sour orange albedo extract and abundant flavanones loaded silica nanoparticles against acrylamide-induced hepatotoxicity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170219/
https://www.ncbi.nlm.nih.gov/pubmed/30294554
http://dx.doi.org/10.1016/j.toxrep.2018.08.021
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