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Voice-selective prediction alterations in nonclinical voice hearers

Auditory verbal hallucinations (AVH) are a cardinal symptom of psychosis but also occur in 6–13% of the general population. Voice perception is thought to engage an internal forward model that generates predictions, preparing the auditory cortex for upcoming sensory feedback. Impaired processing of...

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Autores principales: Pinheiro, Ana P., Schwartze, Michael, Kotz, Sonja A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170384/
https://www.ncbi.nlm.nih.gov/pubmed/30283058
http://dx.doi.org/10.1038/s41598-018-32614-9
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author Pinheiro, Ana P.
Schwartze, Michael
Kotz, Sonja A.
author_facet Pinheiro, Ana P.
Schwartze, Michael
Kotz, Sonja A.
author_sort Pinheiro, Ana P.
collection PubMed
description Auditory verbal hallucinations (AVH) are a cardinal symptom of psychosis but also occur in 6–13% of the general population. Voice perception is thought to engage an internal forward model that generates predictions, preparing the auditory cortex for upcoming sensory feedback. Impaired processing of sensory feedback in vocalization seems to underlie the experience of AVH in psychosis, but whether this is the case in nonclinical voice hearers remains unclear. The current study used electroencephalography (EEG) to investigate whether and how hallucination predisposition (HP) modulates the internal forward model in response to self-initiated tones and self-voices. Participants varying in HP (based on the Launay-Slade Hallucination Scale) listened to self-generated and externally generated tones or self-voices. HP did not affect responses to self vs. externally generated tones. However, HP altered the processing of the self-generated voice: increased HP was associated with increased pre-stimulus alpha power and increased N1 response to the self-generated voice. HP did not affect the P2 response to voices. These findings confirm that both prediction and comparison of predicted and perceived feedback to a self-generated voice are altered in individuals with AVH predisposition. Specific alterations in the processing of self-generated vocalizations may establish a core feature of the psychosis continuum.
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spelling pubmed-61703842018-10-05 Voice-selective prediction alterations in nonclinical voice hearers Pinheiro, Ana P. Schwartze, Michael Kotz, Sonja A. Sci Rep Article Auditory verbal hallucinations (AVH) are a cardinal symptom of psychosis but also occur in 6–13% of the general population. Voice perception is thought to engage an internal forward model that generates predictions, preparing the auditory cortex for upcoming sensory feedback. Impaired processing of sensory feedback in vocalization seems to underlie the experience of AVH in psychosis, but whether this is the case in nonclinical voice hearers remains unclear. The current study used electroencephalography (EEG) to investigate whether and how hallucination predisposition (HP) modulates the internal forward model in response to self-initiated tones and self-voices. Participants varying in HP (based on the Launay-Slade Hallucination Scale) listened to self-generated and externally generated tones or self-voices. HP did not affect responses to self vs. externally generated tones. However, HP altered the processing of the self-generated voice: increased HP was associated with increased pre-stimulus alpha power and increased N1 response to the self-generated voice. HP did not affect the P2 response to voices. These findings confirm that both prediction and comparison of predicted and perceived feedback to a self-generated voice are altered in individuals with AVH predisposition. Specific alterations in the processing of self-generated vocalizations may establish a core feature of the psychosis continuum. Nature Publishing Group UK 2018-10-03 /pmc/articles/PMC6170384/ /pubmed/30283058 http://dx.doi.org/10.1038/s41598-018-32614-9 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Pinheiro, Ana P.
Schwartze, Michael
Kotz, Sonja A.
Voice-selective prediction alterations in nonclinical voice hearers
title Voice-selective prediction alterations in nonclinical voice hearers
title_full Voice-selective prediction alterations in nonclinical voice hearers
title_fullStr Voice-selective prediction alterations in nonclinical voice hearers
title_full_unstemmed Voice-selective prediction alterations in nonclinical voice hearers
title_short Voice-selective prediction alterations in nonclinical voice hearers
title_sort voice-selective prediction alterations in nonclinical voice hearers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170384/
https://www.ncbi.nlm.nih.gov/pubmed/30283058
http://dx.doi.org/10.1038/s41598-018-32614-9
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