YL064 directly inhibits STAT3 activity to induce apoptosis of multiple myeloma cells

Aberrant activation of signal transducer and activator of transcription 3 (STAT3) plays a critical role in the proliferation and survival of multiple myeloma. And inactivation of STAT3 is considered a promising strategy for the treatment of multiple myeloma. Here we show that the sinomenine derivati...

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Detalles Bibliográficos
Autores principales: Wang, Yingying, Wu, Linlin, Cai, Haiyan, Lei, Hu, Ma, Chun-Min, Yang, Li, Xu, Hanzhang, Zhu, Qi, Yao, Zhujun, Wu, Yingli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170385/
https://www.ncbi.nlm.nih.gov/pubmed/30302278
http://dx.doi.org/10.1038/s41420-018-0108-8

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