MYC-containing amplicons in acute myeloid leukemia: genomic structures, evolution, and transcriptional consequences

Double minutes (dmin), homogeneously staining regions, and ring chromosomes are vehicles of gene amplification in cancer. The underlying mechanism leading to their formation as well as their structure and function in acute myeloid leukemia (AML) remain mysterious. We combined a range of high-resolut...

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Detalles Bibliográficos
Autores principales: L′Abbate, Alberto, Tolomeo, Doron, Cifola, Ingrid, Severgnini, Marco, Turchiano, Antonella, Augello, Bartolomeo, Squeo, Gabriella, D′Addabbo, Pietro, Traversa, Debora, Daniele, Giulia, Lonoce, Angelo, Pafundi, Mariella, Carella, Massimo, Palumbo, Orazio, Dolnik, Anna, Muehlematter, Dominique, Schoumans, Jacqueline, Van Roy, Nadine, De Bellis, Gianluca, Martinelli, Giovanni, Merla, Giuseppe, Bullinger, Lars, Haferlach, Claudia, Storlazzi, Clelia Tiziana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170393/
https://www.ncbi.nlm.nih.gov/pubmed/29467491
http://dx.doi.org/10.1038/s41375-018-0033-0

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