Cargando…

First-in-class oral small molecule inhibitor of the tyrosine kinase ROR1 (KAN0439834) induced significant apoptosis of chronic lymphocytic leukemia cells

Detalles Bibliográficos
Autores principales: Hojjat-Farsangi, M., Daneshmanesh, A. H., Khan, A. S., Shetye, J., Mozaffari, F., Kharaziha, P., Rathje, L.-S., Kokhaei, P., Hansson, L., Vågberg, J., Byström, S., Olsson, E., Löfberg, C., Norström, C., Schultz, J., Norin, M., Olin, T., Österborg, A., Mellstedt, H., Moshfegh, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170396/
https://www.ncbi.nlm.nih.gov/pubmed/29725030
http://dx.doi.org/10.1038/s41375-018-0113-1
_version_ 1783360635962130432
author Hojjat-Farsangi, M.
Daneshmanesh, A. H.
Khan, A. S.
Shetye, J.
Mozaffari, F.
Kharaziha, P.
Rathje, L.-S.
Kokhaei, P.
Hansson, L.
Vågberg, J.
Byström, S.
Olsson, E.
Löfberg, C.
Norström, C.
Schultz, J.
Norin, M.
Olin, T.
Österborg, A.
Mellstedt, H.
Moshfegh, A.
author_facet Hojjat-Farsangi, M.
Daneshmanesh, A. H.
Khan, A. S.
Shetye, J.
Mozaffari, F.
Kharaziha, P.
Rathje, L.-S.
Kokhaei, P.
Hansson, L.
Vågberg, J.
Byström, S.
Olsson, E.
Löfberg, C.
Norström, C.
Schultz, J.
Norin, M.
Olin, T.
Österborg, A.
Mellstedt, H.
Moshfegh, A.
author_sort Hojjat-Farsangi, M.
collection PubMed
description
format Online
Article
Text
id pubmed-6170396
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-61703962018-10-09 First-in-class oral small molecule inhibitor of the tyrosine kinase ROR1 (KAN0439834) induced significant apoptosis of chronic lymphocytic leukemia cells Hojjat-Farsangi, M. Daneshmanesh, A. H. Khan, A. S. Shetye, J. Mozaffari, F. Kharaziha, P. Rathje, L.-S. Kokhaei, P. Hansson, L. Vågberg, J. Byström, S. Olsson, E. Löfberg, C. Norström, C. Schultz, J. Norin, M. Olin, T. Österborg, A. Mellstedt, H. Moshfegh, A. Leukemia Brief Communication Nature Publishing Group UK 2018-03-27 2018 /pmc/articles/PMC6170396/ /pubmed/29725030 http://dx.doi.org/10.1038/s41375-018-0113-1 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Brief Communication
Hojjat-Farsangi, M.
Daneshmanesh, A. H.
Khan, A. S.
Shetye, J.
Mozaffari, F.
Kharaziha, P.
Rathje, L.-S.
Kokhaei, P.
Hansson, L.
Vågberg, J.
Byström, S.
Olsson, E.
Löfberg, C.
Norström, C.
Schultz, J.
Norin, M.
Olin, T.
Österborg, A.
Mellstedt, H.
Moshfegh, A.
First-in-class oral small molecule inhibitor of the tyrosine kinase ROR1 (KAN0439834) induced significant apoptosis of chronic lymphocytic leukemia cells
title First-in-class oral small molecule inhibitor of the tyrosine kinase ROR1 (KAN0439834) induced significant apoptosis of chronic lymphocytic leukemia cells
title_full First-in-class oral small molecule inhibitor of the tyrosine kinase ROR1 (KAN0439834) induced significant apoptosis of chronic lymphocytic leukemia cells
title_fullStr First-in-class oral small molecule inhibitor of the tyrosine kinase ROR1 (KAN0439834) induced significant apoptosis of chronic lymphocytic leukemia cells
title_full_unstemmed First-in-class oral small molecule inhibitor of the tyrosine kinase ROR1 (KAN0439834) induced significant apoptosis of chronic lymphocytic leukemia cells
title_short First-in-class oral small molecule inhibitor of the tyrosine kinase ROR1 (KAN0439834) induced significant apoptosis of chronic lymphocytic leukemia cells
title_sort first-in-class oral small molecule inhibitor of the tyrosine kinase ror1 (kan0439834) induced significant apoptosis of chronic lymphocytic leukemia cells
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170396/
https://www.ncbi.nlm.nih.gov/pubmed/29725030
http://dx.doi.org/10.1038/s41375-018-0113-1
work_keys_str_mv AT hojjatfarsangim firstinclassoralsmallmoleculeinhibitorofthetyrosinekinaseror1kan0439834inducedsignificantapoptosisofchroniclymphocyticleukemiacells
AT daneshmaneshah firstinclassoralsmallmoleculeinhibitorofthetyrosinekinaseror1kan0439834inducedsignificantapoptosisofchroniclymphocyticleukemiacells
AT khanas firstinclassoralsmallmoleculeinhibitorofthetyrosinekinaseror1kan0439834inducedsignificantapoptosisofchroniclymphocyticleukemiacells
AT shetyej firstinclassoralsmallmoleculeinhibitorofthetyrosinekinaseror1kan0439834inducedsignificantapoptosisofchroniclymphocyticleukemiacells
AT mozaffarif firstinclassoralsmallmoleculeinhibitorofthetyrosinekinaseror1kan0439834inducedsignificantapoptosisofchroniclymphocyticleukemiacells
AT kharazihap firstinclassoralsmallmoleculeinhibitorofthetyrosinekinaseror1kan0439834inducedsignificantapoptosisofchroniclymphocyticleukemiacells
AT rathjels firstinclassoralsmallmoleculeinhibitorofthetyrosinekinaseror1kan0439834inducedsignificantapoptosisofchroniclymphocyticleukemiacells
AT kokhaeip firstinclassoralsmallmoleculeinhibitorofthetyrosinekinaseror1kan0439834inducedsignificantapoptosisofchroniclymphocyticleukemiacells
AT hanssonl firstinclassoralsmallmoleculeinhibitorofthetyrosinekinaseror1kan0439834inducedsignificantapoptosisofchroniclymphocyticleukemiacells
AT vagbergj firstinclassoralsmallmoleculeinhibitorofthetyrosinekinaseror1kan0439834inducedsignificantapoptosisofchroniclymphocyticleukemiacells
AT bystroms firstinclassoralsmallmoleculeinhibitorofthetyrosinekinaseror1kan0439834inducedsignificantapoptosisofchroniclymphocyticleukemiacells
AT olssone firstinclassoralsmallmoleculeinhibitorofthetyrosinekinaseror1kan0439834inducedsignificantapoptosisofchroniclymphocyticleukemiacells
AT lofbergc firstinclassoralsmallmoleculeinhibitorofthetyrosinekinaseror1kan0439834inducedsignificantapoptosisofchroniclymphocyticleukemiacells
AT norstromc firstinclassoralsmallmoleculeinhibitorofthetyrosinekinaseror1kan0439834inducedsignificantapoptosisofchroniclymphocyticleukemiacells
AT schultzj firstinclassoralsmallmoleculeinhibitorofthetyrosinekinaseror1kan0439834inducedsignificantapoptosisofchroniclymphocyticleukemiacells
AT norinm firstinclassoralsmallmoleculeinhibitorofthetyrosinekinaseror1kan0439834inducedsignificantapoptosisofchroniclymphocyticleukemiacells
AT olint firstinclassoralsmallmoleculeinhibitorofthetyrosinekinaseror1kan0439834inducedsignificantapoptosisofchroniclymphocyticleukemiacells
AT osterborga firstinclassoralsmallmoleculeinhibitorofthetyrosinekinaseror1kan0439834inducedsignificantapoptosisofchroniclymphocyticleukemiacells
AT mellstedth firstinclassoralsmallmoleculeinhibitorofthetyrosinekinaseror1kan0439834inducedsignificantapoptosisofchroniclymphocyticleukemiacells
AT moshfegha firstinclassoralsmallmoleculeinhibitorofthetyrosinekinaseror1kan0439834inducedsignificantapoptosisofchroniclymphocyticleukemiacells