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Rich spatio-temporal stimulus dynamics unveil sensory specialization in cortical area S2

Tactile perception in rodents depends on simultaneous, multi-whisker contacts with objects. Although it is known that neurons in secondary somatosensory cortex (wS2) respond to individual deflections of many whiskers, wS2′s precise function remains unknown. The convergence of information from multip...

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Autores principales: Goldin, Matías A., Harrell, Evan R., Estebanez, Luc, Shulz, Daniel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170455/
https://www.ncbi.nlm.nih.gov/pubmed/30282992
http://dx.doi.org/10.1038/s41467-018-06585-4
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author Goldin, Matías A.
Harrell, Evan R.
Estebanez, Luc
Shulz, Daniel E.
author_facet Goldin, Matías A.
Harrell, Evan R.
Estebanez, Luc
Shulz, Daniel E.
author_sort Goldin, Matías A.
collection PubMed
description Tactile perception in rodents depends on simultaneous, multi-whisker contacts with objects. Although it is known that neurons in secondary somatosensory cortex (wS2) respond to individual deflections of many whiskers, wS2′s precise function remains unknown. The convergence of information from multiple whiskers into wS2 neurons suggests that they are good candidates for integrating multi-whisker information. Here, we apply stimulation patterns with rich dynamics simultaneously to 24 macro-vibrissae of rats while recording large populations of single neurons. Varying inter-whisker correlations without changing single whisker statistics, we observe pronounced supra-linear multi-whisker integration. Using novel analysis methods, we show that continuous multi-whisker movements contribute to the firing of wS2 neurons over long temporal windows, facilitating spatio-temporal integration. In contrast, primary cortex (wS1) neurons encode fine features of whisker movements on precise temporal scales. These results provide the first description of wS2′s representation during multi-whisker stimulation and outline its specialized role in parallel to wS1 tactile processing.
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spelling pubmed-61704552018-10-09 Rich spatio-temporal stimulus dynamics unveil sensory specialization in cortical area S2 Goldin, Matías A. Harrell, Evan R. Estebanez, Luc Shulz, Daniel E. Nat Commun Article Tactile perception in rodents depends on simultaneous, multi-whisker contacts with objects. Although it is known that neurons in secondary somatosensory cortex (wS2) respond to individual deflections of many whiskers, wS2′s precise function remains unknown. The convergence of information from multiple whiskers into wS2 neurons suggests that they are good candidates for integrating multi-whisker information. Here, we apply stimulation patterns with rich dynamics simultaneously to 24 macro-vibrissae of rats while recording large populations of single neurons. Varying inter-whisker correlations without changing single whisker statistics, we observe pronounced supra-linear multi-whisker integration. Using novel analysis methods, we show that continuous multi-whisker movements contribute to the firing of wS2 neurons over long temporal windows, facilitating spatio-temporal integration. In contrast, primary cortex (wS1) neurons encode fine features of whisker movements on precise temporal scales. These results provide the first description of wS2′s representation during multi-whisker stimulation and outline its specialized role in parallel to wS1 tactile processing. Nature Publishing Group UK 2018-10-03 /pmc/articles/PMC6170455/ /pubmed/30282992 http://dx.doi.org/10.1038/s41467-018-06585-4 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Goldin, Matías A.
Harrell, Evan R.
Estebanez, Luc
Shulz, Daniel E.
Rich spatio-temporal stimulus dynamics unveil sensory specialization in cortical area S2
title Rich spatio-temporal stimulus dynamics unveil sensory specialization in cortical area S2
title_full Rich spatio-temporal stimulus dynamics unveil sensory specialization in cortical area S2
title_fullStr Rich spatio-temporal stimulus dynamics unveil sensory specialization in cortical area S2
title_full_unstemmed Rich spatio-temporal stimulus dynamics unveil sensory specialization in cortical area S2
title_short Rich spatio-temporal stimulus dynamics unveil sensory specialization in cortical area S2
title_sort rich spatio-temporal stimulus dynamics unveil sensory specialization in cortical area s2
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170455/
https://www.ncbi.nlm.nih.gov/pubmed/30282992
http://dx.doi.org/10.1038/s41467-018-06585-4
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