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Hydroxypropyl-beta and -gamma cyclodextrins rescue cholesterol accumulation in Niemann–Pick C1 mutant cell via lysosome-associated membrane protein 1

Niemann–Pick type C (NPC) disease is a fatal hereditary neurodegenerative disorder characterized by a massive accumulation of cholesterol in lysosomes and late endosomes due to a defect in intracellular cholesterol trafficking. Dysfunction in intracellular cholesterol trafficking is responsible for...

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Detalles Bibliográficos
Autores principales:	Singhal, Ashutosh, Szente, Lajos, Hildreth, James E. K., Song, Byeongwoon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170477/ https://www.ncbi.nlm.nih.gov/pubmed/30282967 http://dx.doi.org/10.1038/s41419-018-1056-1

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