Impaired tumor growth and angiogenesis in mice heterozygous for Vegfr2 (Flk1)

VEGF signaling through its tyrosine kinase receptor, VEGFR2 (FLK1), is critical for tumor angiogenesis. Previous studies have identified a critical gene dosage effect of VegfA in embryonic development and vessel homeostasis, neovascularization, and tumor growth, and potent inhibitors of VEGFR2 have...

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Detalles Bibliográficos
Autores principales: Oladipupo, Sunday S., Kabir, Ashraf Ul, Smith, Craig, Choi, Kyunghee, Ornitz, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170482/
https://www.ncbi.nlm.nih.gov/pubmed/30283071
http://dx.doi.org/10.1038/s41598-018-33037-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170482/
https://www.ncbi.nlm.nih.gov/pubmed/30283071
http://dx.doi.org/10.1038/s41598-018-33037-2

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