Cargando…
Structural insights into the functional diversity of the CDK–cyclin family
Since their characterization as conserved modules that regulate progression through the eukaryotic cell cycle, cyclin-dependent protein kinases (CDKs) in higher eukaryotic cells are now also emerging as significant regulators of transcription, metabolism and cell differentiation. The cyclins, though...
Autores principales: | Wood, Daniel J., Endicott, Jane A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170502/ https://www.ncbi.nlm.nih.gov/pubmed/30185601 http://dx.doi.org/10.1098/rsob.180112 |
Ejemplares similares
-
Cyclin-Dependent
Kinase (CDK) Inhibitors: Structure–Activity
Relationships and Insights into the CDK-2 Selectivity of 6-Substituted
2-Arylaminopurines
por: Coxon, Christopher R., et al.
Publicado: (2016) -
Cyclin K goes with Cdk12 and Cdk13
por: Kohoutek, Jiri, et al.
Publicado: (2012) -
Discriminative SKP2 Interactions with CDK-Cyclin Complexes Support a Cyclin A-Specific Role in p27KIP1 Degradation
por: Salamina, Marco, et al.
Publicado: (2021) -
Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1
por: Rowland, Rhianna J., et al.
Publicado: (2023) -
Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition
por: Wood, Daniel J., et al.
Publicado: (2019)