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Effect on electrospun fibres by synthesis of high branching polylactic acid
Polylactic electrospun porous fibres have been widely used in tissue engineering scaffolds. However, the application of linear polylactic is limited due to its poor hydrophilicity, which leads to phase separation and has been seldom used in porous fibre preparation. Instead, branching polylactic act...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170545/ https://www.ncbi.nlm.nih.gov/pubmed/30839690 http://dx.doi.org/10.1098/rsos.180134 |
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author | Shen, Wen Zhang, Guanghua Ge, Xuemei Li, Yali Fan, Guodong |
author_facet | Shen, Wen Zhang, Guanghua Ge, Xuemei Li, Yali Fan, Guodong |
author_sort | Shen, Wen |
collection | PubMed |
description | Polylactic electrospun porous fibres have been widely used in tissue engineering scaffolds. However, the application of linear polylactic is limited due to its poor hydrophilicity, which leads to phase separation and has been seldom used in porous fibre preparation. Instead, branching polylactic acts as a new effective method to prepare porous fibres because it can increase polylactic polar property and make it easy to be formulated in the following application. In the current study, we prepared an ultra-high molecular weight of high branching polylactic with glycerol as the initiator by controlling the ring-opening polymerization time, adding amount of catalyst and glycerol. The structure, molecular weight and thermal properties of copolymers were tested subsequently. The result showed that the surface of the high branching polylactic films is smooth, hydrophilic and porous. This branching polylactic formed electrospun porous fibres and possessed a strong adsorption of silver ion. Our study provided a simple and efficient way to synthesize branching polylactic polymer and prepare electrospun porous fibres, which may provide potential applications in the field of biomaterials for tissue engineering or antibacterial dressing compared with the application of linear polylactic and 3-arm polylactic materials. |
format | Online Article Text |
id | pubmed-6170545 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-61705452018-10-18 Effect on electrospun fibres by synthesis of high branching polylactic acid Shen, Wen Zhang, Guanghua Ge, Xuemei Li, Yali Fan, Guodong R Soc Open Sci Chemistry Polylactic electrospun porous fibres have been widely used in tissue engineering scaffolds. However, the application of linear polylactic is limited due to its poor hydrophilicity, which leads to phase separation and has been seldom used in porous fibre preparation. Instead, branching polylactic acts as a new effective method to prepare porous fibres because it can increase polylactic polar property and make it easy to be formulated in the following application. In the current study, we prepared an ultra-high molecular weight of high branching polylactic with glycerol as the initiator by controlling the ring-opening polymerization time, adding amount of catalyst and glycerol. The structure, molecular weight and thermal properties of copolymers were tested subsequently. The result showed that the surface of the high branching polylactic films is smooth, hydrophilic and porous. This branching polylactic formed electrospun porous fibres and possessed a strong adsorption of silver ion. Our study provided a simple and efficient way to synthesize branching polylactic polymer and prepare electrospun porous fibres, which may provide potential applications in the field of biomaterials for tissue engineering or antibacterial dressing compared with the application of linear polylactic and 3-arm polylactic materials. The Royal Society 2018-09-12 /pmc/articles/PMC6170545/ /pubmed/30839690 http://dx.doi.org/10.1098/rsos.180134 Text en © 2018 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Chemistry Shen, Wen Zhang, Guanghua Ge, Xuemei Li, Yali Fan, Guodong Effect on electrospun fibres by synthesis of high branching polylactic acid |
title | Effect on electrospun fibres by synthesis of high branching polylactic acid |
title_full | Effect on electrospun fibres by synthesis of high branching polylactic acid |
title_fullStr | Effect on electrospun fibres by synthesis of high branching polylactic acid |
title_full_unstemmed | Effect on electrospun fibres by synthesis of high branching polylactic acid |
title_short | Effect on electrospun fibres by synthesis of high branching polylactic acid |
title_sort | effect on electrospun fibres by synthesis of high branching polylactic acid |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170545/ https://www.ncbi.nlm.nih.gov/pubmed/30839690 http://dx.doi.org/10.1098/rsos.180134 |
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