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The Challenge of the Pathogenesis of Parkinson's Disease: Is Autoimmunity the Culprit?

The role of autoimmunity in Parkinson's disease (PD), as one of the most popular research subjects, has been intensively investigated in recent years. Although the ultimate cause of PD is unknown, one major area of interest remains identifying new therapeutic targets and options for patients su...

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Detalles Bibliográficos
Autores principales: Jiang, Tianfang, Li, Gen, Xu, Jun, Gao, Shane, Chen, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170625/
https://www.ncbi.nlm.nih.gov/pubmed/30319601
http://dx.doi.org/10.3389/fimmu.2018.02047
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author Jiang, Tianfang
Li, Gen
Xu, Jun
Gao, Shane
Chen, Xu
author_facet Jiang, Tianfang
Li, Gen
Xu, Jun
Gao, Shane
Chen, Xu
author_sort Jiang, Tianfang
collection PubMed
description The role of autoimmunity in Parkinson's disease (PD), as one of the most popular research subjects, has been intensively investigated in recent years. Although the ultimate cause of PD is unknown, one major area of interest remains identifying new therapeutic targets and options for patients suffering from PD. Herein, we present a comprehensive review of the impacts of autoimmunity in neurodegenerative diseases, especially PD, and we have composed a logical argument to substantiate that autoimmunity is actively involved in the pathogenesis of PD through several proteins, including α-synuclein, DJ-1, PINK1, and Parkin, as well as immune cells, such as dendritic cells, microglia, T cells, and B cells. Furthermore, a detailed analysis of the relevance of autoimmunity to the clinical symptoms of PD provides strong evidence for the close correlation of autoimmunity with PD. In addition, the previously identified relationships between other autoimmune diseases and PD help us to better understand the disease pattern, laying the foundation for new therapeutic solutions to PD. In summary, this review aims to integrate and present currently available data to clarify the pathogenesis of PD and discuss some controversial but innovative research perspectives on the involvement of autoimmunity in PD, as well as possible novel diagnostic methods and treatments based on autoimmunity targets.
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spelling pubmed-61706252018-10-12 The Challenge of the Pathogenesis of Parkinson's Disease: Is Autoimmunity the Culprit? Jiang, Tianfang Li, Gen Xu, Jun Gao, Shane Chen, Xu Front Immunol Immunology The role of autoimmunity in Parkinson's disease (PD), as one of the most popular research subjects, has been intensively investigated in recent years. Although the ultimate cause of PD is unknown, one major area of interest remains identifying new therapeutic targets and options for patients suffering from PD. Herein, we present a comprehensive review of the impacts of autoimmunity in neurodegenerative diseases, especially PD, and we have composed a logical argument to substantiate that autoimmunity is actively involved in the pathogenesis of PD through several proteins, including α-synuclein, DJ-1, PINK1, and Parkin, as well as immune cells, such as dendritic cells, microglia, T cells, and B cells. Furthermore, a detailed analysis of the relevance of autoimmunity to the clinical symptoms of PD provides strong evidence for the close correlation of autoimmunity with PD. In addition, the previously identified relationships between other autoimmune diseases and PD help us to better understand the disease pattern, laying the foundation for new therapeutic solutions to PD. In summary, this review aims to integrate and present currently available data to clarify the pathogenesis of PD and discuss some controversial but innovative research perspectives on the involvement of autoimmunity in PD, as well as possible novel diagnostic methods and treatments based on autoimmunity targets. Frontiers Media S.A. 2018-09-27 /pmc/articles/PMC6170625/ /pubmed/30319601 http://dx.doi.org/10.3389/fimmu.2018.02047 Text en Copyright © 2018 Jiang, Li, Xu, Gao and Chen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Jiang, Tianfang
Li, Gen
Xu, Jun
Gao, Shane
Chen, Xu
The Challenge of the Pathogenesis of Parkinson's Disease: Is Autoimmunity the Culprit?
title The Challenge of the Pathogenesis of Parkinson's Disease: Is Autoimmunity the Culprit?
title_full The Challenge of the Pathogenesis of Parkinson's Disease: Is Autoimmunity the Culprit?
title_fullStr The Challenge of the Pathogenesis of Parkinson's Disease: Is Autoimmunity the Culprit?
title_full_unstemmed The Challenge of the Pathogenesis of Parkinson's Disease: Is Autoimmunity the Culprit?
title_short The Challenge of the Pathogenesis of Parkinson's Disease: Is Autoimmunity the Culprit?
title_sort challenge of the pathogenesis of parkinson's disease: is autoimmunity the culprit?
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170625/
https://www.ncbi.nlm.nih.gov/pubmed/30319601
http://dx.doi.org/10.3389/fimmu.2018.02047
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