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Primary cilium and glioblastoma

Glioblastoma (GBM) represents the most common, malignant and lethal primary brain tumour in adults. The primary cilium is a highly conserved and dynamic organelle that protrudes from the apical surface of virtually every type of mammalian cell. There is increasing evidence that abnormal cilia are in...

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Detalles Bibliográficos
Autores principales: Álvarez-Satta, María, Matheu, Ander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170955/
https://www.ncbi.nlm.nih.gov/pubmed/30302130
http://dx.doi.org/10.1177/1758835918801169
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author Álvarez-Satta, María
Matheu, Ander
author_facet Álvarez-Satta, María
Matheu, Ander
author_sort Álvarez-Satta, María
collection PubMed
description Glioblastoma (GBM) represents the most common, malignant and lethal primary brain tumour in adults. The primary cilium is a highly conserved and dynamic organelle that protrudes from the apical surface of virtually every type of mammalian cell. There is increasing evidence that abnormal cilia are involved in cancer progression, since primary cilia regulate cell cycle and signalling transduction. In this review, we summarize the role of primary cilium specifically with regard to GBM, where there is evidence postulating it as a critical mediator of GBM tumorigenesis and progression. This opens the way to the application of cilia-targeted therapies (‘ciliotherapy’) as a new approach in the fight against this devastating tumour.
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spelling pubmed-61709552018-10-09 Primary cilium and glioblastoma Álvarez-Satta, María Matheu, Ander Ther Adv Med Oncol Review Glioblastoma (GBM) represents the most common, malignant and lethal primary brain tumour in adults. The primary cilium is a highly conserved and dynamic organelle that protrudes from the apical surface of virtually every type of mammalian cell. There is increasing evidence that abnormal cilia are involved in cancer progression, since primary cilia regulate cell cycle and signalling transduction. In this review, we summarize the role of primary cilium specifically with regard to GBM, where there is evidence postulating it as a critical mediator of GBM tumorigenesis and progression. This opens the way to the application of cilia-targeted therapies (‘ciliotherapy’) as a new approach in the fight against this devastating tumour. SAGE Publications 2018-10-03 /pmc/articles/PMC6170955/ /pubmed/30302130 http://dx.doi.org/10.1177/1758835918801169 Text en © The Author(s), 2018 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Álvarez-Satta, María
Matheu, Ander
Primary cilium and glioblastoma
title Primary cilium and glioblastoma
title_full Primary cilium and glioblastoma
title_fullStr Primary cilium and glioblastoma
title_full_unstemmed Primary cilium and glioblastoma
title_short Primary cilium and glioblastoma
title_sort primary cilium and glioblastoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170955/
https://www.ncbi.nlm.nih.gov/pubmed/30302130
http://dx.doi.org/10.1177/1758835918801169
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