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Prognostic impact of high c-Met expression in ovarian cancer: a meta-analysis
High c-Met expression has been observed in epithelial ovarian cancer (EOC). However, its clinicopathological impacts remain controversial. We conducted this meta-analysis to evaluate the pathologic and prognostic significance of c-Met overexpression in patients with EOC. A systematic computerized se...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171012/ https://www.ncbi.nlm.nih.gov/pubmed/30310499 http://dx.doi.org/10.7150/jca.26071 |
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author | Kim, Jung Han Jang, Hyun Joo Kim, Hyeong Su Kim, Bum Jun Park, Sung Ho |
author_facet | Kim, Jung Han Jang, Hyun Joo Kim, Hyeong Su Kim, Bum Jun Park, Sung Ho |
author_sort | Kim, Jung Han |
collection | PubMed |
description | High c-Met expression has been observed in epithelial ovarian cancer (EOC). However, its clinicopathological impacts remain controversial. We conducted this meta-analysis to evaluate the pathologic and prognostic significance of c-Met overexpression in patients with EOC. A systematic computerized search of the electronic databases PubMed, PMC, EMBASE, and Google scholar (up to April 2018) was carried out. From seven studies, 568 patients with EOC were included in the meta-analysis. Although there was no statistical significance, EOCs with c-Met overexpression tended to show higher FIGO stage (III-IV) (odds ratio = 2.18, 95% confidence interval: 0.86-5.53, p = 0.10) and higher rate of lymph node metastasis (odds ratio = 3.05, 95% confidence interval: 0.85-10.98, p = 0.09), compared with tumors with low c-Met expression. In terms of prognosis, patients with c-Met-high EOC showed significantly worse survival than those with c-Met-low tumor (hazard ratio = 2.11, 95% confidence interval: 1.51-2.94, p < 0.0001). In conclusion, this meta-analysis indicates that high c-Met expression represents an adverse prognostic marker for patients with EOC. |
format | Online Article Text |
id | pubmed-6171012 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-61710122018-10-11 Prognostic impact of high c-Met expression in ovarian cancer: a meta-analysis Kim, Jung Han Jang, Hyun Joo Kim, Hyeong Su Kim, Bum Jun Park, Sung Ho J Cancer Research Paper High c-Met expression has been observed in epithelial ovarian cancer (EOC). However, its clinicopathological impacts remain controversial. We conducted this meta-analysis to evaluate the pathologic and prognostic significance of c-Met overexpression in patients with EOC. A systematic computerized search of the electronic databases PubMed, PMC, EMBASE, and Google scholar (up to April 2018) was carried out. From seven studies, 568 patients with EOC were included in the meta-analysis. Although there was no statistical significance, EOCs with c-Met overexpression tended to show higher FIGO stage (III-IV) (odds ratio = 2.18, 95% confidence interval: 0.86-5.53, p = 0.10) and higher rate of lymph node metastasis (odds ratio = 3.05, 95% confidence interval: 0.85-10.98, p = 0.09), compared with tumors with low c-Met expression. In terms of prognosis, patients with c-Met-high EOC showed significantly worse survival than those with c-Met-low tumor (hazard ratio = 2.11, 95% confidence interval: 1.51-2.94, p < 0.0001). In conclusion, this meta-analysis indicates that high c-Met expression represents an adverse prognostic marker for patients with EOC. Ivyspring International Publisher 2018-09-08 /pmc/articles/PMC6171012/ /pubmed/30310499 http://dx.doi.org/10.7150/jca.26071 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Research Paper Kim, Jung Han Jang, Hyun Joo Kim, Hyeong Su Kim, Bum Jun Park, Sung Ho Prognostic impact of high c-Met expression in ovarian cancer: a meta-analysis |
title | Prognostic impact of high c-Met expression in ovarian cancer: a meta-analysis |
title_full | Prognostic impact of high c-Met expression in ovarian cancer: a meta-analysis |
title_fullStr | Prognostic impact of high c-Met expression in ovarian cancer: a meta-analysis |
title_full_unstemmed | Prognostic impact of high c-Met expression in ovarian cancer: a meta-analysis |
title_short | Prognostic impact of high c-Met expression in ovarian cancer: a meta-analysis |
title_sort | prognostic impact of high c-met expression in ovarian cancer: a meta-analysis |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171012/ https://www.ncbi.nlm.nih.gov/pubmed/30310499 http://dx.doi.org/10.7150/jca.26071 |
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