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Characteristics of lung cancer among patients with idiopathic pulmonary fibrosis and interstitial lung disease – analysis of institutional and population data

BACKGROUND: Lung Cancer is occasionally observed in patients with Idiopathic Pulmonary Fibrosis (IPF). We sought to describe the epidemiologic and clinical characteristics of lung cancer for patients with IPF and other interstitial lung disease (ILD) using institutional and statewide data registries...

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Autores principales: Yoon, Joo Heung, Nouraie, Mehdi, Chen, Xiaoping, Zou, Richard H, Sellares, Jacobo, Veraldi, Kristen L, Chiarchiaro, Jared, Lindell, Kathleen, Wilson, David O, Kaminski, Naftali, Burns, Timothy, Trejo Bittar, Humberto, Yousem, Samuel, Gibson, Kevin, Kass, Daniel J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171146/
https://www.ncbi.nlm.nih.gov/pubmed/30285867
http://dx.doi.org/10.1186/s12931-018-0899-4
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author Yoon, Joo Heung
Nouraie, Mehdi
Chen, Xiaoping
Zou, Richard H
Sellares, Jacobo
Veraldi, Kristen L
Chiarchiaro, Jared
Lindell, Kathleen
Wilson, David O
Kaminski, Naftali
Burns, Timothy
Trejo Bittar, Humberto
Yousem, Samuel
Gibson, Kevin
Kass, Daniel J
author_facet Yoon, Joo Heung
Nouraie, Mehdi
Chen, Xiaoping
Zou, Richard H
Sellares, Jacobo
Veraldi, Kristen L
Chiarchiaro, Jared
Lindell, Kathleen
Wilson, David O
Kaminski, Naftali
Burns, Timothy
Trejo Bittar, Humberto
Yousem, Samuel
Gibson, Kevin
Kass, Daniel J
author_sort Yoon, Joo Heung
collection PubMed
description BACKGROUND: Lung Cancer is occasionally observed in patients with Idiopathic Pulmonary Fibrosis (IPF). We sought to describe the epidemiologic and clinical characteristics of lung cancer for patients with IPF and other interstitial lung disease (ILD) using institutional and statewide data registries. METHODS: We conducted a retrospective analysis of IPF and non-IPF ILD patients from the ILD center registry, to compare with lung cancer registries at the University of Pittsburgh as well as with population data of lung cancer obtained from Pennsylvania Department of Health between 2000 and 2015. RESULTS: Among 1108 IPF patients, 31 patients were identified with IPF and lung cancer. The age-adjusted standard incidence ratio of lung cancer was 3.34 (with IPF) and 2.3 (with non-IPF ILD) (between-group Hazard ratio = 1.4, p = 0.3). Lung cancer worsened the mortality of IPF (p <  0.001). Lung cancer with IPF had higher mortality compared to lung cancer in non-IPF ILD (Hazard ratio = 6.2, p = 0.001). Lung cancer among IPF was characterized by a predilection for lower lobes (63% vs. 26% in non-IPF lung cancer, p <  0.001) and by squamous cell histology (41% vs. 29%, p = 0.07). Increased incidence of lung cancer was observed among single lung transplant (SLT) recipients for IPF (13 out of 97, 13.4%), with increased mortality compared to SLT for IPF without lung cancer (p = 0.028) during observational period. CONCLUSIONS: Lung cancer is approximately 3.34 times more frequently diagnosed in IPF patients compared to general population, and associated with worse prognosis compared with IPF without lung cancer, with squamous cell carcinoma and lower lobe predilection. The causality between non-smoking IPF patients and lung cancer is to be determined. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12931-018-0899-4) contains supplementary material, which is available to authorized users.
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spelling pubmed-61711462018-10-10 Characteristics of lung cancer among patients with idiopathic pulmonary fibrosis and interstitial lung disease – analysis of institutional and population data Yoon, Joo Heung Nouraie, Mehdi Chen, Xiaoping Zou, Richard H Sellares, Jacobo Veraldi, Kristen L Chiarchiaro, Jared Lindell, Kathleen Wilson, David O Kaminski, Naftali Burns, Timothy Trejo Bittar, Humberto Yousem, Samuel Gibson, Kevin Kass, Daniel J Respir Res Research BACKGROUND: Lung Cancer is occasionally observed in patients with Idiopathic Pulmonary Fibrosis (IPF). We sought to describe the epidemiologic and clinical characteristics of lung cancer for patients with IPF and other interstitial lung disease (ILD) using institutional and statewide data registries. METHODS: We conducted a retrospective analysis of IPF and non-IPF ILD patients from the ILD center registry, to compare with lung cancer registries at the University of Pittsburgh as well as with population data of lung cancer obtained from Pennsylvania Department of Health between 2000 and 2015. RESULTS: Among 1108 IPF patients, 31 patients were identified with IPF and lung cancer. The age-adjusted standard incidence ratio of lung cancer was 3.34 (with IPF) and 2.3 (with non-IPF ILD) (between-group Hazard ratio = 1.4, p = 0.3). Lung cancer worsened the mortality of IPF (p <  0.001). Lung cancer with IPF had higher mortality compared to lung cancer in non-IPF ILD (Hazard ratio = 6.2, p = 0.001). Lung cancer among IPF was characterized by a predilection for lower lobes (63% vs. 26% in non-IPF lung cancer, p <  0.001) and by squamous cell histology (41% vs. 29%, p = 0.07). Increased incidence of lung cancer was observed among single lung transplant (SLT) recipients for IPF (13 out of 97, 13.4%), with increased mortality compared to SLT for IPF without lung cancer (p = 0.028) during observational period. CONCLUSIONS: Lung cancer is approximately 3.34 times more frequently diagnosed in IPF patients compared to general population, and associated with worse prognosis compared with IPF without lung cancer, with squamous cell carcinoma and lower lobe predilection. The causality between non-smoking IPF patients and lung cancer is to be determined. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12931-018-0899-4) contains supplementary material, which is available to authorized users. BioMed Central 2018-10-03 2018 /pmc/articles/PMC6171146/ /pubmed/30285867 http://dx.doi.org/10.1186/s12931-018-0899-4 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Yoon, Joo Heung
Nouraie, Mehdi
Chen, Xiaoping
Zou, Richard H
Sellares, Jacobo
Veraldi, Kristen L
Chiarchiaro, Jared
Lindell, Kathleen
Wilson, David O
Kaminski, Naftali
Burns, Timothy
Trejo Bittar, Humberto
Yousem, Samuel
Gibson, Kevin
Kass, Daniel J
Characteristics of lung cancer among patients with idiopathic pulmonary fibrosis and interstitial lung disease – analysis of institutional and population data
title Characteristics of lung cancer among patients with idiopathic pulmonary fibrosis and interstitial lung disease – analysis of institutional and population data
title_full Characteristics of lung cancer among patients with idiopathic pulmonary fibrosis and interstitial lung disease – analysis of institutional and population data
title_fullStr Characteristics of lung cancer among patients with idiopathic pulmonary fibrosis and interstitial lung disease – analysis of institutional and population data
title_full_unstemmed Characteristics of lung cancer among patients with idiopathic pulmonary fibrosis and interstitial lung disease – analysis of institutional and population data
title_short Characteristics of lung cancer among patients with idiopathic pulmonary fibrosis and interstitial lung disease – analysis of institutional and population data
title_sort characteristics of lung cancer among patients with idiopathic pulmonary fibrosis and interstitial lung disease – analysis of institutional and population data
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171146/
https://www.ncbi.nlm.nih.gov/pubmed/30285867
http://dx.doi.org/10.1186/s12931-018-0899-4
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