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Intraoperative Local Administration of Platelet-Rich Plasma (PRP) during Neurolysis Surgery for the Treatment of Digital Nerve Crush Injury
The digital nerves are important for normal hand function. In addition to conventional therapies such as neurolysis, direct repair, and auto/allografts, new treatments administering growth factors and cells for promoting nerve regeneration exist. Platelet-rich plasma (PRP), an autologous product wit...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171255/ https://www.ncbi.nlm.nih.gov/pubmed/30327740 http://dx.doi.org/10.1155/2018/1275713 |
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author | Ikumi, Akira Hara, Yuki Okano, Eriko Kohyama, Sho Arai, Norihito Taniguchi, Yu Sugaya, Hisashi Yoshioka, Tomokazu Kanamori, Akihiro Yamazaki, Masashi |
author_facet | Ikumi, Akira Hara, Yuki Okano, Eriko Kohyama, Sho Arai, Norihito Taniguchi, Yu Sugaya, Hisashi Yoshioka, Tomokazu Kanamori, Akihiro Yamazaki, Masashi |
author_sort | Ikumi, Akira |
collection | PubMed |
description | The digital nerves are important for normal hand function. In addition to conventional therapies such as neurolysis, direct repair, and auto/allografts, new treatments administering growth factors and cells for promoting nerve regeneration exist. Platelet-rich plasma (PRP), an autologous product with proven therapeutic effects for musculoskeletal disorders, is a new treatment option for peripheral nerve injury. We hypothesized that PRP could stimulate healing of digital nerve injuries. In the current case report, intraoperative local administration of PRP was performed during neurolysis surgery for a healthy 28-year-old woman with digital nerve crush injury. Five weeks postinjury, surgery was performed due to severe uncontrollable neuropathic pain and no sensory nerve action potential derivation of the index finger. Therapeutic effects were assessed by physical examination, visual analog scale for pain, and nerve conduction study. Postoperatively, early neuropathic pain relief and good functional recovery were obtained with no PRP-related adverse events. This case report demonstrates the therapeutic potential of intraoperative PRP to enhance the healing process of nerve crush injury in the acute phase and to decrease the neuropathic pain, thus enhancing healing of peripheral nerve crush injury. |
format | Online Article Text |
id | pubmed-6171255 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-61712552018-10-16 Intraoperative Local Administration of Platelet-Rich Plasma (PRP) during Neurolysis Surgery for the Treatment of Digital Nerve Crush Injury Ikumi, Akira Hara, Yuki Okano, Eriko Kohyama, Sho Arai, Norihito Taniguchi, Yu Sugaya, Hisashi Yoshioka, Tomokazu Kanamori, Akihiro Yamazaki, Masashi Case Rep Orthop Case Report The digital nerves are important for normal hand function. In addition to conventional therapies such as neurolysis, direct repair, and auto/allografts, new treatments administering growth factors and cells for promoting nerve regeneration exist. Platelet-rich plasma (PRP), an autologous product with proven therapeutic effects for musculoskeletal disorders, is a new treatment option for peripheral nerve injury. We hypothesized that PRP could stimulate healing of digital nerve injuries. In the current case report, intraoperative local administration of PRP was performed during neurolysis surgery for a healthy 28-year-old woman with digital nerve crush injury. Five weeks postinjury, surgery was performed due to severe uncontrollable neuropathic pain and no sensory nerve action potential derivation of the index finger. Therapeutic effects were assessed by physical examination, visual analog scale for pain, and nerve conduction study. Postoperatively, early neuropathic pain relief and good functional recovery were obtained with no PRP-related adverse events. This case report demonstrates the therapeutic potential of intraoperative PRP to enhance the healing process of nerve crush injury in the acute phase and to decrease the neuropathic pain, thus enhancing healing of peripheral nerve crush injury. Hindawi 2018-09-20 /pmc/articles/PMC6171255/ /pubmed/30327740 http://dx.doi.org/10.1155/2018/1275713 Text en Copyright © 2018 Akira Ikumi et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Ikumi, Akira Hara, Yuki Okano, Eriko Kohyama, Sho Arai, Norihito Taniguchi, Yu Sugaya, Hisashi Yoshioka, Tomokazu Kanamori, Akihiro Yamazaki, Masashi Intraoperative Local Administration of Platelet-Rich Plasma (PRP) during Neurolysis Surgery for the Treatment of Digital Nerve Crush Injury |
title | Intraoperative Local Administration of Platelet-Rich Plasma (PRP) during Neurolysis Surgery for the Treatment of Digital Nerve Crush Injury |
title_full | Intraoperative Local Administration of Platelet-Rich Plasma (PRP) during Neurolysis Surgery for the Treatment of Digital Nerve Crush Injury |
title_fullStr | Intraoperative Local Administration of Platelet-Rich Plasma (PRP) during Neurolysis Surgery for the Treatment of Digital Nerve Crush Injury |
title_full_unstemmed | Intraoperative Local Administration of Platelet-Rich Plasma (PRP) during Neurolysis Surgery for the Treatment of Digital Nerve Crush Injury |
title_short | Intraoperative Local Administration of Platelet-Rich Plasma (PRP) during Neurolysis Surgery for the Treatment of Digital Nerve Crush Injury |
title_sort | intraoperative local administration of platelet-rich plasma (prp) during neurolysis surgery for the treatment of digital nerve crush injury |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171255/ https://www.ncbi.nlm.nih.gov/pubmed/30327740 http://dx.doi.org/10.1155/2018/1275713 |
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