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Kynurenic Acid Protects against Thioacetamide-Induced Liver Injury in Rats

Acute liver failure (ALF) is a life-threatening disorder of liver function. Kynurenic acid (KYNA), a tryptophan metabolite formed along the kynurenine metabolic pathway, possesses anti-inflammatory and antioxidant properties. Its presence in food and its potential role in the digestive system was re...

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Autores principales: Marciniak, Sebastian, Wnorowski, Artur, Smolińska, Katarzyna, Walczyna, Beata, Turski, Waldemar, Kocki, Tomasz, Paluszkiewicz, Piotr, Parada-Turska, Jolanta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171262/
https://www.ncbi.nlm.nih.gov/pubmed/30327755
http://dx.doi.org/10.1155/2018/1270483
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author Marciniak, Sebastian
Wnorowski, Artur
Smolińska, Katarzyna
Walczyna, Beata
Turski, Waldemar
Kocki, Tomasz
Paluszkiewicz, Piotr
Parada-Turska, Jolanta
author_facet Marciniak, Sebastian
Wnorowski, Artur
Smolińska, Katarzyna
Walczyna, Beata
Turski, Waldemar
Kocki, Tomasz
Paluszkiewicz, Piotr
Parada-Turska, Jolanta
author_sort Marciniak, Sebastian
collection PubMed
description Acute liver failure (ALF) is a life-threatening disorder of liver function. Kynurenic acid (KYNA), a tryptophan metabolite formed along the kynurenine metabolic pathway, possesses anti-inflammatory and antioxidant properties. Its presence in food and its potential role in the digestive system was recently reported. The aim of this study was to define the effect of KYNA on liver failure. The Wistar rat model of thioacetamide-induced liver injury was used. Morphological and biochemical analyses as well as the measurement of KYNA content in liver and hepatoprotective herbal remedies were conducted. The significant attenuation of morphological disturbances and aspartate and alanine transaminase activities, decrease of myeloperoxidase and tumor necrosis factor-α, and elevation of interleukin-10 levels indicating the protective effect of KYNA in thioacetamide (TAA) - induced liver injury were discovered. In conclusion, the hepatoprotective role of KYNA in an animal model of liver failure was documented and the use of KYNA in the treatment of ALF was suggested.
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spelling pubmed-61712622018-10-16 Kynurenic Acid Protects against Thioacetamide-Induced Liver Injury in Rats Marciniak, Sebastian Wnorowski, Artur Smolińska, Katarzyna Walczyna, Beata Turski, Waldemar Kocki, Tomasz Paluszkiewicz, Piotr Parada-Turska, Jolanta Anal Cell Pathol (Amst) Research Article Acute liver failure (ALF) is a life-threatening disorder of liver function. Kynurenic acid (KYNA), a tryptophan metabolite formed along the kynurenine metabolic pathway, possesses anti-inflammatory and antioxidant properties. Its presence in food and its potential role in the digestive system was recently reported. The aim of this study was to define the effect of KYNA on liver failure. The Wistar rat model of thioacetamide-induced liver injury was used. Morphological and biochemical analyses as well as the measurement of KYNA content in liver and hepatoprotective herbal remedies were conducted. The significant attenuation of morphological disturbances and aspartate and alanine transaminase activities, decrease of myeloperoxidase and tumor necrosis factor-α, and elevation of interleukin-10 levels indicating the protective effect of KYNA in thioacetamide (TAA) - induced liver injury were discovered. In conclusion, the hepatoprotective role of KYNA in an animal model of liver failure was documented and the use of KYNA in the treatment of ALF was suggested. Hindawi 2018-09-20 /pmc/articles/PMC6171262/ /pubmed/30327755 http://dx.doi.org/10.1155/2018/1270483 Text en Copyright © 2018 Sebastian Marciniak et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Marciniak, Sebastian
Wnorowski, Artur
Smolińska, Katarzyna
Walczyna, Beata
Turski, Waldemar
Kocki, Tomasz
Paluszkiewicz, Piotr
Parada-Turska, Jolanta
Kynurenic Acid Protects against Thioacetamide-Induced Liver Injury in Rats
title Kynurenic Acid Protects against Thioacetamide-Induced Liver Injury in Rats
title_full Kynurenic Acid Protects against Thioacetamide-Induced Liver Injury in Rats
title_fullStr Kynurenic Acid Protects against Thioacetamide-Induced Liver Injury in Rats
title_full_unstemmed Kynurenic Acid Protects against Thioacetamide-Induced Liver Injury in Rats
title_short Kynurenic Acid Protects against Thioacetamide-Induced Liver Injury in Rats
title_sort kynurenic acid protects against thioacetamide-induced liver injury in rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171262/
https://www.ncbi.nlm.nih.gov/pubmed/30327755
http://dx.doi.org/10.1155/2018/1270483
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