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Kynurenic Acid Protects against Thioacetamide-Induced Liver Injury in Rats
Acute liver failure (ALF) is a life-threatening disorder of liver function. Kynurenic acid (KYNA), a tryptophan metabolite formed along the kynurenine metabolic pathway, possesses anti-inflammatory and antioxidant properties. Its presence in food and its potential role in the digestive system was re...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171262/ https://www.ncbi.nlm.nih.gov/pubmed/30327755 http://dx.doi.org/10.1155/2018/1270483 |
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author | Marciniak, Sebastian Wnorowski, Artur Smolińska, Katarzyna Walczyna, Beata Turski, Waldemar Kocki, Tomasz Paluszkiewicz, Piotr Parada-Turska, Jolanta |
author_facet | Marciniak, Sebastian Wnorowski, Artur Smolińska, Katarzyna Walczyna, Beata Turski, Waldemar Kocki, Tomasz Paluszkiewicz, Piotr Parada-Turska, Jolanta |
author_sort | Marciniak, Sebastian |
collection | PubMed |
description | Acute liver failure (ALF) is a life-threatening disorder of liver function. Kynurenic acid (KYNA), a tryptophan metabolite formed along the kynurenine metabolic pathway, possesses anti-inflammatory and antioxidant properties. Its presence in food and its potential role in the digestive system was recently reported. The aim of this study was to define the effect of KYNA on liver failure. The Wistar rat model of thioacetamide-induced liver injury was used. Morphological and biochemical analyses as well as the measurement of KYNA content in liver and hepatoprotective herbal remedies were conducted. The significant attenuation of morphological disturbances and aspartate and alanine transaminase activities, decrease of myeloperoxidase and tumor necrosis factor-α, and elevation of interleukin-10 levels indicating the protective effect of KYNA in thioacetamide (TAA) - induced liver injury were discovered. In conclusion, the hepatoprotective role of KYNA in an animal model of liver failure was documented and the use of KYNA in the treatment of ALF was suggested. |
format | Online Article Text |
id | pubmed-6171262 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-61712622018-10-16 Kynurenic Acid Protects against Thioacetamide-Induced Liver Injury in Rats Marciniak, Sebastian Wnorowski, Artur Smolińska, Katarzyna Walczyna, Beata Turski, Waldemar Kocki, Tomasz Paluszkiewicz, Piotr Parada-Turska, Jolanta Anal Cell Pathol (Amst) Research Article Acute liver failure (ALF) is a life-threatening disorder of liver function. Kynurenic acid (KYNA), a tryptophan metabolite formed along the kynurenine metabolic pathway, possesses anti-inflammatory and antioxidant properties. Its presence in food and its potential role in the digestive system was recently reported. The aim of this study was to define the effect of KYNA on liver failure. The Wistar rat model of thioacetamide-induced liver injury was used. Morphological and biochemical analyses as well as the measurement of KYNA content in liver and hepatoprotective herbal remedies were conducted. The significant attenuation of morphological disturbances and aspartate and alanine transaminase activities, decrease of myeloperoxidase and tumor necrosis factor-α, and elevation of interleukin-10 levels indicating the protective effect of KYNA in thioacetamide (TAA) - induced liver injury were discovered. In conclusion, the hepatoprotective role of KYNA in an animal model of liver failure was documented and the use of KYNA in the treatment of ALF was suggested. Hindawi 2018-09-20 /pmc/articles/PMC6171262/ /pubmed/30327755 http://dx.doi.org/10.1155/2018/1270483 Text en Copyright © 2018 Sebastian Marciniak et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Marciniak, Sebastian Wnorowski, Artur Smolińska, Katarzyna Walczyna, Beata Turski, Waldemar Kocki, Tomasz Paluszkiewicz, Piotr Parada-Turska, Jolanta Kynurenic Acid Protects against Thioacetamide-Induced Liver Injury in Rats |
title | Kynurenic Acid Protects against Thioacetamide-Induced Liver Injury in Rats |
title_full | Kynurenic Acid Protects against Thioacetamide-Induced Liver Injury in Rats |
title_fullStr | Kynurenic Acid Protects against Thioacetamide-Induced Liver Injury in Rats |
title_full_unstemmed | Kynurenic Acid Protects against Thioacetamide-Induced Liver Injury in Rats |
title_short | Kynurenic Acid Protects against Thioacetamide-Induced Liver Injury in Rats |
title_sort | kynurenic acid protects against thioacetamide-induced liver injury in rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171262/ https://www.ncbi.nlm.nih.gov/pubmed/30327755 http://dx.doi.org/10.1155/2018/1270483 |
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