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CRISPR/Cas9-mediated genome editing induces gene knockdown by altering the pre-mRNA splicing in mice

BACKGROUND: Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR associated protein 9 (CRISPR/Cas9) has been wildly used to generate gene knockout models through inducing indels causing frame-shift. However, there are few studies concerning the post-transcript effects caused by CRISPR-me...

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Detalles Bibliográficos
Autores principales:	Tang, Ji-Xin, Chen, Dafeng, Deng, Shou-Long, Li, Jian, Li, Yuanyuan, Fu, Zheng, Wang, Xiu-Xia, Zhang, Yan, Chen, Su-Ren, Liu, Yi-Xun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Methodology Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171314/ https://www.ncbi.nlm.nih.gov/pubmed/30285700 http://dx.doi.org/10.1186/s12896-018-0472-8

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