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Hydroxycobalamin catalyzes the oxidation of diethyldithiocarbamate and increases its cytotoxicity independently of copper ions

It is known that some metals (Cu, Zn, Cd, Au) markedly increase the toxic effect of thiocarbamates. It was shown in the present study that hydroxycobalamin (a form of vitamin B(12), HOCbl), which incorporates cobalt, significantly enhances the cytotoxicity of diethyldithiocarbamate (DDC), decreasing...

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Detalles Bibliográficos
Autores principales:	Solovieva, M.E., Shatalin, Yu.V., Solovyev, V.V., Sazonov, A.V., Kutyshenko, V.P., Akatov, V.S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171330/ https://www.ncbi.nlm.nih.gov/pubmed/30290302 http://dx.doi.org/10.1016/j.redox.2018.09.016

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