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Main Risk Factors Association with Proto-Oncogene Mutations in Colorectal Cancer

OBJECTIVE: Although several factors have been shown to have etiological roles in colorectal cancer, few investigations have addressed how and to what extent these factors affect the genetics and pathology of the disease. Precise relationships with specific genetic mutations that could alter signalin...

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Autores principales: Dolatkhah, Roya, Somi, Mohammad Hossein, Shabanloei, Reza, Farassati, Faris, Fakhari, Ali, Dastgiri, Saeed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171391/
https://www.ncbi.nlm.nih.gov/pubmed/30139223
http://dx.doi.org/10.22034/APJCP.2018.19.8.2183
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author Dolatkhah, Roya
Somi, Mohammad Hossein
Shabanloei, Reza
Farassati, Faris
Fakhari, Ali
Dastgiri, Saeed
author_facet Dolatkhah, Roya
Somi, Mohammad Hossein
Shabanloei, Reza
Farassati, Faris
Fakhari, Ali
Dastgiri, Saeed
author_sort Dolatkhah, Roya
collection PubMed
description OBJECTIVE: Although several factors have been shown to have etiological roles in colorectal cancer, few investigations have addressed how and to what extent these factors affect the genetics and pathology of the disease. Precise relationships with specific genetic mutations that could alter signaling pathways involved in colorectal cancer remain unknown. We therefore aimed to investigate possible links between lifestyle, dietary habits, and socioeconomic factors and specific mutations that are common in colorectal cancers. METHODS: Data were retrieved from a baseline survey of lifestyle factors, dietary behavior, and SES, as well as anthropometric evaluations during a physical examination, for 100 confirmed primary sporadic colorectal cancer patients from Northwest Iran. RESULTS: High socioeconomic status was significantly associated with higher likelihood of a KRAS gene mutation (P < 0.05) (odds ratio: 3.01; 95% CI: 0.69–13.02). Consuming carbohydrates and alcohol, working less, and having a sedentary lifestyle also increased the odds of having a KRAS mutation. CONCLUSION: Although research has not yet described the exact relationships among genetic mutations with different known risk factors in colorectal cancer, examples of the latter may have an impact on KRAS gene mutations.
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spelling pubmed-61713912018-10-15 Main Risk Factors Association with Proto-Oncogene Mutations in Colorectal Cancer Dolatkhah, Roya Somi, Mohammad Hossein Shabanloei, Reza Farassati, Faris Fakhari, Ali Dastgiri, Saeed Asian Pac J Cancer Prev Research Article OBJECTIVE: Although several factors have been shown to have etiological roles in colorectal cancer, few investigations have addressed how and to what extent these factors affect the genetics and pathology of the disease. Precise relationships with specific genetic mutations that could alter signaling pathways involved in colorectal cancer remain unknown. We therefore aimed to investigate possible links between lifestyle, dietary habits, and socioeconomic factors and specific mutations that are common in colorectal cancers. METHODS: Data were retrieved from a baseline survey of lifestyle factors, dietary behavior, and SES, as well as anthropometric evaluations during a physical examination, for 100 confirmed primary sporadic colorectal cancer patients from Northwest Iran. RESULTS: High socioeconomic status was significantly associated with higher likelihood of a KRAS gene mutation (P < 0.05) (odds ratio: 3.01; 95% CI: 0.69–13.02). Consuming carbohydrates and alcohol, working less, and having a sedentary lifestyle also increased the odds of having a KRAS mutation. CONCLUSION: Although research has not yet described the exact relationships among genetic mutations with different known risk factors in colorectal cancer, examples of the latter may have an impact on KRAS gene mutations. West Asia Organization for Cancer Prevention 2018 /pmc/articles/PMC6171391/ /pubmed/30139223 http://dx.doi.org/10.22034/APJCP.2018.19.8.2183 Text en Copyright: © Asian Pacific Journal of Cancer Prevention http://creativecommons.org/licenses/BY-SA/4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
spellingShingle Research Article
Dolatkhah, Roya
Somi, Mohammad Hossein
Shabanloei, Reza
Farassati, Faris
Fakhari, Ali
Dastgiri, Saeed
Main Risk Factors Association with Proto-Oncogene Mutations in Colorectal Cancer
title Main Risk Factors Association with Proto-Oncogene Mutations in Colorectal Cancer
title_full Main Risk Factors Association with Proto-Oncogene Mutations in Colorectal Cancer
title_fullStr Main Risk Factors Association with Proto-Oncogene Mutations in Colorectal Cancer
title_full_unstemmed Main Risk Factors Association with Proto-Oncogene Mutations in Colorectal Cancer
title_short Main Risk Factors Association with Proto-Oncogene Mutations in Colorectal Cancer
title_sort main risk factors association with proto-oncogene mutations in colorectal cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171391/
https://www.ncbi.nlm.nih.gov/pubmed/30139223
http://dx.doi.org/10.22034/APJCP.2018.19.8.2183
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