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Betaine enhances the cellular survival via mitochondrial fusion and fission factors, MFN2 and DRP1

Betaine is a key metabolite of the methionine cycle and known for attenuating alcoholic steatosis in the liver. Recent studies have focused on the protection effect of betaine in mitochondrial regulation through the enhanced oxidative phosphorylation system. However, the mechanisms of its beneficial...

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Autor principal: Jung Kim, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171430/
https://www.ncbi.nlm.nih.gov/pubmed/30460110
http://dx.doi.org/10.1080/19768354.2018.1512523
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author Jung Kim, Min
author_facet Jung Kim, Min
author_sort Jung Kim, Min
collection PubMed
description Betaine is a key metabolite of the methionine cycle and known for attenuating alcoholic steatosis in the liver. Recent studies have focused on the protection effect of betaine in mitochondrial regulation through the enhanced oxidative phosphorylation system. However, the mechanisms of its beneficial effects have not been clearly identified yet. Mitochondrial dynamics is important for the maintenance of functional mitochondria and cell homeostasis. A defective mitochondrial dynamics and oxidative phosphorylation system have been closely linked to several pathologies, raising the possibility that novel drugs targeting mitochondrial dynamics may present a therapeutic potential to restore the cellular homeostasis. In this study, we investigated betaine’s effect on mitochondrial morphology and physiology and demonstrated that betaine enhances mitochondrial function by increasing mitochondrial fusion and improves cell survival. Furthermore, it rescued the unbalance of the mitochondrial dynamics from mitochondrial oxidative phosphorylation dysfunction induced by oligomycin and rotenone. The elongation properties by betaine were accompanied by lowering DRP1 and increasing MFN2 expression. These data suggest that betaine could play an important role in remodeling mitochondrial dynamics to enhance mitochondrial function and cell viability.
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spelling pubmed-61714302018-11-20 Betaine enhances the cellular survival via mitochondrial fusion and fission factors, MFN2 and DRP1 Jung Kim, Min Anim Cells Syst (Seoul) Articles Betaine is a key metabolite of the methionine cycle and known for attenuating alcoholic steatosis in the liver. Recent studies have focused on the protection effect of betaine in mitochondrial regulation through the enhanced oxidative phosphorylation system. However, the mechanisms of its beneficial effects have not been clearly identified yet. Mitochondrial dynamics is important for the maintenance of functional mitochondria and cell homeostasis. A defective mitochondrial dynamics and oxidative phosphorylation system have been closely linked to several pathologies, raising the possibility that novel drugs targeting mitochondrial dynamics may present a therapeutic potential to restore the cellular homeostasis. In this study, we investigated betaine’s effect on mitochondrial morphology and physiology and demonstrated that betaine enhances mitochondrial function by increasing mitochondrial fusion and improves cell survival. Furthermore, it rescued the unbalance of the mitochondrial dynamics from mitochondrial oxidative phosphorylation dysfunction induced by oligomycin and rotenone. The elongation properties by betaine were accompanied by lowering DRP1 and increasing MFN2 expression. These data suggest that betaine could play an important role in remodeling mitochondrial dynamics to enhance mitochondrial function and cell viability. Taylor & Francis 2018-08-30 /pmc/articles/PMC6171430/ /pubmed/30460110 http://dx.doi.org/10.1080/19768354.2018.1512523 Text en © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Jung Kim, Min
Betaine enhances the cellular survival via mitochondrial fusion and fission factors, MFN2 and DRP1
title Betaine enhances the cellular survival via mitochondrial fusion and fission factors, MFN2 and DRP1
title_full Betaine enhances the cellular survival via mitochondrial fusion and fission factors, MFN2 and DRP1
title_fullStr Betaine enhances the cellular survival via mitochondrial fusion and fission factors, MFN2 and DRP1
title_full_unstemmed Betaine enhances the cellular survival via mitochondrial fusion and fission factors, MFN2 and DRP1
title_short Betaine enhances the cellular survival via mitochondrial fusion and fission factors, MFN2 and DRP1
title_sort betaine enhances the cellular survival via mitochondrial fusion and fission factors, mfn2 and drp1
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171430/
https://www.ncbi.nlm.nih.gov/pubmed/30460110
http://dx.doi.org/10.1080/19768354.2018.1512523
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