NOP7 interacts with β-catenin and activates β-catenin/TCF signaling in hepatocellular carcinoma cells

BACKGROUND: The hyperactivation of β-catenin signaling is frequently observed in clinical hepatocellular carcinoma (HCC) samples. Further understanding the mechanisms involved in activating β-catenin/TCF signaling would benefit the treatment of HCC. METHOD AND RESULTS: Here, it was found that NOP7 w...

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Autores principales: Wu, Nan, Zhao, Jing, Yuan, Youhua, Lu, Chuanjia, Zhu, Wenjing, Jiang, Qun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171516/
https://www.ncbi.nlm.nih.gov/pubmed/30319277
http://dx.doi.org/10.2147/OTT.S164601
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author Wu, Nan
Zhao, Jing
Yuan, Youhua
Lu, Chuanjia
Zhu, Wenjing
Jiang, Qun
author_facet Wu, Nan
Zhao, Jing
Yuan, Youhua
Lu, Chuanjia
Zhu, Wenjing
Jiang, Qun
author_sort Wu, Nan
collection PubMed
description BACKGROUND: The hyperactivation of β-catenin signaling is frequently observed in clinical hepatocellular carcinoma (HCC) samples. Further understanding the mechanisms involved in activating β-catenin/TCF signaling would benefit the treatment of HCC. METHOD AND RESULTS: Here, it was found that NOP7 was a binding partner of β-catenin. NOP7 strengthened the interaction between β-catenin and TCF4, which led to the activation of β-catenin/TCF signaling. The upregulation of NOP7 in HCC promoted the growth (in both liquid culture and soft agar) and migration of HCC cancer cells. CONCLUSION: Taken together, we have demonstrated the oncogenic functions of NOP7 in HCC, suggesting that targeting NOP7 would benefit the treatment of HCC.
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spelling pubmed-61715162018-10-12 NOP7 interacts with β-catenin and activates β-catenin/TCF signaling in hepatocellular carcinoma cells Wu, Nan Zhao, Jing Yuan, Youhua Lu, Chuanjia Zhu, Wenjing Jiang, Qun Onco Targets Ther Original Research BACKGROUND: The hyperactivation of β-catenin signaling is frequently observed in clinical hepatocellular carcinoma (HCC) samples. Further understanding the mechanisms involved in activating β-catenin/TCF signaling would benefit the treatment of HCC. METHOD AND RESULTS: Here, it was found that NOP7 was a binding partner of β-catenin. NOP7 strengthened the interaction between β-catenin and TCF4, which led to the activation of β-catenin/TCF signaling. The upregulation of NOP7 in HCC promoted the growth (in both liquid culture and soft agar) and migration of HCC cancer cells. CONCLUSION: Taken together, we have demonstrated the oncogenic functions of NOP7 in HCC, suggesting that targeting NOP7 would benefit the treatment of HCC. Dove Medical Press 2018-10-01 /pmc/articles/PMC6171516/ /pubmed/30319277 http://dx.doi.org/10.2147/OTT.S164601 Text en © 2018 Wu et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed
spellingShingle Original Research
Wu, Nan
Zhao, Jing
Yuan, Youhua
Lu, Chuanjia
Zhu, Wenjing
Jiang, Qun
NOP7 interacts with β-catenin and activates β-catenin/TCF signaling in hepatocellular carcinoma cells
title NOP7 interacts with β-catenin and activates β-catenin/TCF signaling in hepatocellular carcinoma cells
title_full NOP7 interacts with β-catenin and activates β-catenin/TCF signaling in hepatocellular carcinoma cells
title_fullStr NOP7 interacts with β-catenin and activates β-catenin/TCF signaling in hepatocellular carcinoma cells
title_full_unstemmed NOP7 interacts with β-catenin and activates β-catenin/TCF signaling in hepatocellular carcinoma cells
title_short NOP7 interacts with β-catenin and activates β-catenin/TCF signaling in hepatocellular carcinoma cells
title_sort nop7 interacts with β-catenin and activates β-catenin/tcf signaling in hepatocellular carcinoma cells
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171516/
https://www.ncbi.nlm.nih.gov/pubmed/30319277
http://dx.doi.org/10.2147/OTT.S164601
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