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Advanced nanomaterials targeting hypoxia to enhance radiotherapy

Hypoxia within solid tumors is often responsible for the failure of radiotherapy. The development of hypoxia-targeting nanomaterials – aimed at enhancing the effect of radiotherapy by electrical or heat effects and at modulating hypoxia in the tumor microenvironment – is a promising strategy to addr...

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Detalles Bibliográficos
Autores principales: Li, Jia, Shang, Wenting, Li, Yong, Fu, Sirui, Tian, Jie, Lu, Ligong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171520/
https://www.ncbi.nlm.nih.gov/pubmed/30319257
http://dx.doi.org/10.2147/IJN.S173914
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author Li, Jia
Shang, Wenting
Li, Yong
Fu, Sirui
Tian, Jie
Lu, Ligong
author_facet Li, Jia
Shang, Wenting
Li, Yong
Fu, Sirui
Tian, Jie
Lu, Ligong
author_sort Li, Jia
collection PubMed
description Hypoxia within solid tumors is often responsible for the failure of radiotherapy. The development of hypoxia-targeting nanomaterials – aimed at enhancing the effect of radiotherapy by electrical or heat effects and at modulating hypoxia in the tumor microenvironment – is a promising strategy to address this issue. We provide an overview of recently developed advanced materials that potentiate radiotherapy. First, we summarize novel materials for oxygen delivery or production to modify the tumor microenvironment, thus improving the effects of ionizing radiation. Second, we present new approaches for the design of high-Z element–based multifunctional nanoplatforms to enhance radiotherapy. Third, novel drug delivery systems for hypoxic regions and hypoxia-inducible factor-1–targeted therapies are discussed. Fourth, we establish the effectiveness of X-ray- or near-infrared–responsive nanoparticles for selectively triggering therapeutic effects under hypoxic conditions. Finally, this review emphasizes the importance of research in the field of nanomedicine focused on tumor hypoxia to improve clinical outcomes.
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spelling pubmed-61715202018-10-12 Advanced nanomaterials targeting hypoxia to enhance radiotherapy Li, Jia Shang, Wenting Li, Yong Fu, Sirui Tian, Jie Lu, Ligong Int J Nanomedicine Review Hypoxia within solid tumors is often responsible for the failure of radiotherapy. The development of hypoxia-targeting nanomaterials – aimed at enhancing the effect of radiotherapy by electrical or heat effects and at modulating hypoxia in the tumor microenvironment – is a promising strategy to address this issue. We provide an overview of recently developed advanced materials that potentiate radiotherapy. First, we summarize novel materials for oxygen delivery or production to modify the tumor microenvironment, thus improving the effects of ionizing radiation. Second, we present new approaches for the design of high-Z element–based multifunctional nanoplatforms to enhance radiotherapy. Third, novel drug delivery systems for hypoxic regions and hypoxia-inducible factor-1–targeted therapies are discussed. Fourth, we establish the effectiveness of X-ray- or near-infrared–responsive nanoparticles for selectively triggering therapeutic effects under hypoxic conditions. Finally, this review emphasizes the importance of research in the field of nanomedicine focused on tumor hypoxia to improve clinical outcomes. Dove Medical Press 2018-10-01 /pmc/articles/PMC6171520/ /pubmed/30319257 http://dx.doi.org/10.2147/IJN.S173914 Text en © 2018 Li et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Li, Jia
Shang, Wenting
Li, Yong
Fu, Sirui
Tian, Jie
Lu, Ligong
Advanced nanomaterials targeting hypoxia to enhance radiotherapy
title Advanced nanomaterials targeting hypoxia to enhance radiotherapy
title_full Advanced nanomaterials targeting hypoxia to enhance radiotherapy
title_fullStr Advanced nanomaterials targeting hypoxia to enhance radiotherapy
title_full_unstemmed Advanced nanomaterials targeting hypoxia to enhance radiotherapy
title_short Advanced nanomaterials targeting hypoxia to enhance radiotherapy
title_sort advanced nanomaterials targeting hypoxia to enhance radiotherapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171520/
https://www.ncbi.nlm.nih.gov/pubmed/30319257
http://dx.doi.org/10.2147/IJN.S173914
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