Drug-induced Thrombotic Microangiopathy Caused by Gemcitabine

Hemolytic uremic syndrome (HUS) is the triad of nonimmune (Coombs negative) hemolytic anemia, low platelet count, and renal impairment. HUS has been associated with a variety of gastrointestinal malignancies and chemotherapeutic agents. We present a patient with pancreatic cancer treated with gemcit...

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Detalles Bibliográficos
Autores principales: Hasan, Askari, Jain, Akriti G, Naim, Huda, Munaf, Alvina, Everett, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2018
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171780/
https://www.ncbi.nlm.nih.gov/pubmed/30324044
http://dx.doi.org/10.7759/cureus.3088
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author Hasan, Askari
Jain, Akriti G
Naim, Huda
Munaf, Alvina
Everett, George
author_facet Hasan, Askari
Jain, Akriti G
Naim, Huda
Munaf, Alvina
Everett, George
author_sort Hasan, Askari
collection PubMed
description Hemolytic uremic syndrome (HUS) is the triad of nonimmune (Coombs negative) hemolytic anemia, low platelet count, and renal impairment. HUS has been associated with a variety of gastrointestinal malignancies and chemotherapeutic agents. We present a patient with pancreatic cancer treated with gemcitabine for palliation who developed gemcitabine‐induced HUS (GiHUS) which responded to some extent to blood and platelet transfusions. With the increase in the use of gemcitabine therapy for pancreatic and other malignancies, it is essential to accurately and timely diagnose GiHUS to avoid the life-threatening complications.
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spelling pubmed-61717802018-10-15 Drug-induced Thrombotic Microangiopathy Caused by Gemcitabine Hasan, Askari Jain, Akriti G Naim, Huda Munaf, Alvina Everett, George Cureus Internal Medicine Hemolytic uremic syndrome (HUS) is the triad of nonimmune (Coombs negative) hemolytic anemia, low platelet count, and renal impairment. HUS has been associated with a variety of gastrointestinal malignancies and chemotherapeutic agents. We present a patient with pancreatic cancer treated with gemcitabine for palliation who developed gemcitabine‐induced HUS (GiHUS) which responded to some extent to blood and platelet transfusions. With the increase in the use of gemcitabine therapy for pancreatic and other malignancies, it is essential to accurately and timely diagnose GiHUS to avoid the life-threatening complications. Cureus 2018-08-02 /pmc/articles/PMC6171780/ /pubmed/30324044 http://dx.doi.org/10.7759/cureus.3088 Text en Copyright © 2018, Hasan et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Hasan, Askari
Jain, Akriti G
Naim, Huda
Munaf, Alvina
Everett, George
Drug-induced Thrombotic Microangiopathy Caused by Gemcitabine
title Drug-induced Thrombotic Microangiopathy Caused by Gemcitabine
title_full Drug-induced Thrombotic Microangiopathy Caused by Gemcitabine
title_fullStr Drug-induced Thrombotic Microangiopathy Caused by Gemcitabine
title_full_unstemmed Drug-induced Thrombotic Microangiopathy Caused by Gemcitabine
title_short Drug-induced Thrombotic Microangiopathy Caused by Gemcitabine
title_sort drug-induced thrombotic microangiopathy caused by gemcitabine
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171780/
https://www.ncbi.nlm.nih.gov/pubmed/30324044
http://dx.doi.org/10.7759/cureus.3088
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AT munafalvina druginducedthromboticmicroangiopathycausedbygemcitabine
AT everettgeorge druginducedthromboticmicroangiopathycausedbygemcitabine

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