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The clinical relevance of ABO blood type in 100 patients with acute subdural hematoma

OBJECTIVE: The correlation of depleted blood through midline shift in acute subdural hematoma remains the most reliable clinical predictor to date. On the other hand, patient’s ABO blood type has a profound impact on coagulation and hemostasis. We conducted this study to evaluate the role of patient...

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Autores principales: Dubinski, Daniel, Won, Sae-Yeon, Behmanesh, Bedjan, Brawanski, Nina, Geisen, Christof, Seifert, Volker, Senft, Christian, Konczalla, Juergen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171832/
https://www.ncbi.nlm.nih.gov/pubmed/30286106
http://dx.doi.org/10.1371/journal.pone.0204331
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author Dubinski, Daniel
Won, Sae-Yeon
Behmanesh, Bedjan
Brawanski, Nina
Geisen, Christof
Seifert, Volker
Senft, Christian
Konczalla, Juergen
author_facet Dubinski, Daniel
Won, Sae-Yeon
Behmanesh, Bedjan
Brawanski, Nina
Geisen, Christof
Seifert, Volker
Senft, Christian
Konczalla, Juergen
author_sort Dubinski, Daniel
collection PubMed
description OBJECTIVE: The correlation of depleted blood through midline shift in acute subdural hematoma remains the most reliable clinical predictor to date. On the other hand, patient’s ABO blood type has a profound impact on coagulation and hemostasis. We conducted this study to evaluate the role of patient’s blood type in terms of incidence, clinical course and outcome after acute subdural hematoma bleeding. METHODS: 100 patients with acute subdural hematoma treated between 2010 and 2015 at the author’s institution were included. Baseline characteristics and clinical findings including Glasgow coma scale, Glasgow outcome scale, hematoma volume, rebleeding, midline shift, postoperative seizures and the presence of anticoagulation were analyzed for their association with ABO blood type. RESULTS: Patient’s with blood type O were found to have a lower midline shift (p<0.01) and significantly less seizures (OR: 0.43; p<0.05) compared to non-O patients. Furthermore, patients with blood type A had the a significantly higher midline shift (p<0.05) and a significantly increased risk for postoperative seizures (OR: 4.01; p<0.001). There was no difference in ABO blood type distribution between acute subdural hematoma patients and the average population. CONCLUSION: The ABO blood type has significant influence on acute subdural hematoma sequelae. Patient’s with blood type O benefit in their clinical course after acute subdural hematoma whereas blood type A patients are at highest risk for increased midline shift and postoperative seizures. Further studies elucidating the biological mechanisms of blood type depended hemostaseology and its role in acute subdural hematoma are required for the development of an appropriate intervention.
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spelling pubmed-61718322018-10-19 The clinical relevance of ABO blood type in 100 patients with acute subdural hematoma Dubinski, Daniel Won, Sae-Yeon Behmanesh, Bedjan Brawanski, Nina Geisen, Christof Seifert, Volker Senft, Christian Konczalla, Juergen PLoS One Research Article OBJECTIVE: The correlation of depleted blood through midline shift in acute subdural hematoma remains the most reliable clinical predictor to date. On the other hand, patient’s ABO blood type has a profound impact on coagulation and hemostasis. We conducted this study to evaluate the role of patient’s blood type in terms of incidence, clinical course and outcome after acute subdural hematoma bleeding. METHODS: 100 patients with acute subdural hematoma treated between 2010 and 2015 at the author’s institution were included. Baseline characteristics and clinical findings including Glasgow coma scale, Glasgow outcome scale, hematoma volume, rebleeding, midline shift, postoperative seizures and the presence of anticoagulation were analyzed for their association with ABO blood type. RESULTS: Patient’s with blood type O were found to have a lower midline shift (p<0.01) and significantly less seizures (OR: 0.43; p<0.05) compared to non-O patients. Furthermore, patients with blood type A had the a significantly higher midline shift (p<0.05) and a significantly increased risk for postoperative seizures (OR: 4.01; p<0.001). There was no difference in ABO blood type distribution between acute subdural hematoma patients and the average population. CONCLUSION: The ABO blood type has significant influence on acute subdural hematoma sequelae. Patient’s with blood type O benefit in their clinical course after acute subdural hematoma whereas blood type A patients are at highest risk for increased midline shift and postoperative seizures. Further studies elucidating the biological mechanisms of blood type depended hemostaseology and its role in acute subdural hematoma are required for the development of an appropriate intervention. Public Library of Science 2018-10-04 /pmc/articles/PMC6171832/ /pubmed/30286106 http://dx.doi.org/10.1371/journal.pone.0204331 Text en © 2018 Dubinski et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Dubinski, Daniel
Won, Sae-Yeon
Behmanesh, Bedjan
Brawanski, Nina
Geisen, Christof
Seifert, Volker
Senft, Christian
Konczalla, Juergen
The clinical relevance of ABO blood type in 100 patients with acute subdural hematoma
title The clinical relevance of ABO blood type in 100 patients with acute subdural hematoma
title_full The clinical relevance of ABO blood type in 100 patients with acute subdural hematoma
title_fullStr The clinical relevance of ABO blood type in 100 patients with acute subdural hematoma
title_full_unstemmed The clinical relevance of ABO blood type in 100 patients with acute subdural hematoma
title_short The clinical relevance of ABO blood type in 100 patients with acute subdural hematoma
title_sort clinical relevance of abo blood type in 100 patients with acute subdural hematoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171832/
https://www.ncbi.nlm.nih.gov/pubmed/30286106
http://dx.doi.org/10.1371/journal.pone.0204331
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