Cargando…

Health-related quality of life in patients with autoimmune hepatitis: A questionnaire survey

AIM: Health-related quality of life is impaired in patients with autoimmune hepatitis, but the association between health-related quality of life and patients’ backgrounds remains unknown. We assessed health-related quality of life in patients with autoimmune hepatitis and identified factors associa...

Descripción completa

Detalles Bibliográficos
Autores principales: Takahashi, Atsushi, Moriya, Kei, Ohira, Hiromasa, Arinaga-Hino, Teruko, Zeniya, Mikio, Torimura, Takuji, Abe, Masanori, Takaki, Akinobu, Kang, Jong-Hon, Inui, Ayano, Fujisawa, Tomoo, Yoshizawa, Kaname, Suzuki, Yoshiyuki, Nakamoto, Nobuhiro, Koike, Kazuhiko, Yoshiji, Hitoshi, Goto, Aya, Tanaka, Atsushi, Younossi, Zobair M., Takikawa, Hajime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171853/
https://www.ncbi.nlm.nih.gov/pubmed/30286131
http://dx.doi.org/10.1371/journal.pone.0204772
_version_ 1783360836414210048
author Takahashi, Atsushi
Moriya, Kei
Ohira, Hiromasa
Arinaga-Hino, Teruko
Zeniya, Mikio
Torimura, Takuji
Abe, Masanori
Takaki, Akinobu
Kang, Jong-Hon
Inui, Ayano
Fujisawa, Tomoo
Yoshizawa, Kaname
Suzuki, Yoshiyuki
Nakamoto, Nobuhiro
Koike, Kazuhiko
Yoshiji, Hitoshi
Goto, Aya
Tanaka, Atsushi
Younossi, Zobair M.
Takikawa, Hajime
author_facet Takahashi, Atsushi
Moriya, Kei
Ohira, Hiromasa
Arinaga-Hino, Teruko
Zeniya, Mikio
Torimura, Takuji
Abe, Masanori
Takaki, Akinobu
Kang, Jong-Hon
Inui, Ayano
Fujisawa, Tomoo
Yoshizawa, Kaname
Suzuki, Yoshiyuki
Nakamoto, Nobuhiro
Koike, Kazuhiko
Yoshiji, Hitoshi
Goto, Aya
Tanaka, Atsushi
Younossi, Zobair M.
Takikawa, Hajime
author_sort Takahashi, Atsushi
collection PubMed
description AIM: Health-related quality of life is impaired in patients with autoimmune hepatitis, but the association between health-related quality of life and patients’ backgrounds remains unknown. We assessed health-related quality of life in patients with autoimmune hepatitis and identified factors associated with its impairment. METHODS: We assessed health-related quality of life in patients with autoimmune hepatitis, patients with chronic hepatitis C, and healthy subjects using the Japanese version of the Chronic Liver Disease Questionnaire and the 36-Item Short Form Survey. We compared health-related quality of life in patients with autoimmune hepatitis with that of patients with chronic hepatitis C and healthy subjects. RESULTS: A total of 265 patients with autoimmune hepatitis, 88 patients with chronic hepatitis C, and 97 healthy subjects were enrolled; most patients were women. The median ages of patients were 65, 66, and 57 years, respectively. Of these patients with autoimmune hepatitis, 10.6% and 57.0% had cirrhosis and comorbid diseases, respectively. The overall Chronic Liver Disease Questionnaire scores (5.5 vs. 6.2, P < 0.001) and physical (48.1 vs. 54.2, P < 0.001) and mental (51.8 vs. 55.0, P = 0.004) component summaries of 36-Item Short Form Survey were significantly lower in patients with autoimmune hepatitis than in healthy subjects, and similar to scores in patients with chronic hepatitis C. Having cirrhosis, comorbid diseases, and treatment for autoimmune hepatitis were associated with impaired health-related quality of life among patients with autoimmune hepatitis. In particular, prednisolone use was associated with lower scores on the worry domain of the Chronic Liver Disease Questionnaire. CONCLUSIONS: Patients with autoimmune hepatitis showed impairment in health-related quality of life, which was associated with not only disease progression, but also comorbid diseases and treatment. Ways to improve health-related quality of life should be considered in patients with AIH when disease outcome is not favorable and when using prednisolone.
format Online
Article
Text
id pubmed-6171853
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-61718532018-10-19 Health-related quality of life in patients with autoimmune hepatitis: A questionnaire survey Takahashi, Atsushi Moriya, Kei Ohira, Hiromasa Arinaga-Hino, Teruko Zeniya, Mikio Torimura, Takuji Abe, Masanori Takaki, Akinobu Kang, Jong-Hon Inui, Ayano Fujisawa, Tomoo Yoshizawa, Kaname Suzuki, Yoshiyuki Nakamoto, Nobuhiro Koike, Kazuhiko Yoshiji, Hitoshi Goto, Aya Tanaka, Atsushi Younossi, Zobair M. Takikawa, Hajime PLoS One Research Article AIM: Health-related quality of life is impaired in patients with autoimmune hepatitis, but the association between health-related quality of life and patients’ backgrounds remains unknown. We assessed health-related quality of life in patients with autoimmune hepatitis and identified factors associated with its impairment. METHODS: We assessed health-related quality of life in patients with autoimmune hepatitis, patients with chronic hepatitis C, and healthy subjects using the Japanese version of the Chronic Liver Disease Questionnaire and the 36-Item Short Form Survey. We compared health-related quality of life in patients with autoimmune hepatitis with that of patients with chronic hepatitis C and healthy subjects. RESULTS: A total of 265 patients with autoimmune hepatitis, 88 patients with chronic hepatitis C, and 97 healthy subjects were enrolled; most patients were women. The median ages of patients were 65, 66, and 57 years, respectively. Of these patients with autoimmune hepatitis, 10.6% and 57.0% had cirrhosis and comorbid diseases, respectively. The overall Chronic Liver Disease Questionnaire scores (5.5 vs. 6.2, P < 0.001) and physical (48.1 vs. 54.2, P < 0.001) and mental (51.8 vs. 55.0, P = 0.004) component summaries of 36-Item Short Form Survey were significantly lower in patients with autoimmune hepatitis than in healthy subjects, and similar to scores in patients with chronic hepatitis C. Having cirrhosis, comorbid diseases, and treatment for autoimmune hepatitis were associated with impaired health-related quality of life among patients with autoimmune hepatitis. In particular, prednisolone use was associated with lower scores on the worry domain of the Chronic Liver Disease Questionnaire. CONCLUSIONS: Patients with autoimmune hepatitis showed impairment in health-related quality of life, which was associated with not only disease progression, but also comorbid diseases and treatment. Ways to improve health-related quality of life should be considered in patients with AIH when disease outcome is not favorable and when using prednisolone. Public Library of Science 2018-10-04 /pmc/articles/PMC6171853/ /pubmed/30286131 http://dx.doi.org/10.1371/journal.pone.0204772 Text en © 2018 Takahashi et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Takahashi, Atsushi
Moriya, Kei
Ohira, Hiromasa
Arinaga-Hino, Teruko
Zeniya, Mikio
Torimura, Takuji
Abe, Masanori
Takaki, Akinobu
Kang, Jong-Hon
Inui, Ayano
Fujisawa, Tomoo
Yoshizawa, Kaname
Suzuki, Yoshiyuki
Nakamoto, Nobuhiro
Koike, Kazuhiko
Yoshiji, Hitoshi
Goto, Aya
Tanaka, Atsushi
Younossi, Zobair M.
Takikawa, Hajime
Health-related quality of life in patients with autoimmune hepatitis: A questionnaire survey
title Health-related quality of life in patients with autoimmune hepatitis: A questionnaire survey
title_full Health-related quality of life in patients with autoimmune hepatitis: A questionnaire survey
title_fullStr Health-related quality of life in patients with autoimmune hepatitis: A questionnaire survey
title_full_unstemmed Health-related quality of life in patients with autoimmune hepatitis: A questionnaire survey
title_short Health-related quality of life in patients with autoimmune hepatitis: A questionnaire survey
title_sort health-related quality of life in patients with autoimmune hepatitis: a questionnaire survey
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171853/
https://www.ncbi.nlm.nih.gov/pubmed/30286131
http://dx.doi.org/10.1371/journal.pone.0204772
work_keys_str_mv AT takahashiatsushi healthrelatedqualityoflifeinpatientswithautoimmunehepatitisaquestionnairesurvey
AT moriyakei healthrelatedqualityoflifeinpatientswithautoimmunehepatitisaquestionnairesurvey
AT ohirahiromasa healthrelatedqualityoflifeinpatientswithautoimmunehepatitisaquestionnairesurvey
AT arinagahinoteruko healthrelatedqualityoflifeinpatientswithautoimmunehepatitisaquestionnairesurvey
AT zeniyamikio healthrelatedqualityoflifeinpatientswithautoimmunehepatitisaquestionnairesurvey
AT torimuratakuji healthrelatedqualityoflifeinpatientswithautoimmunehepatitisaquestionnairesurvey
AT abemasanori healthrelatedqualityoflifeinpatientswithautoimmunehepatitisaquestionnairesurvey
AT takakiakinobu healthrelatedqualityoflifeinpatientswithautoimmunehepatitisaquestionnairesurvey
AT kangjonghon healthrelatedqualityoflifeinpatientswithautoimmunehepatitisaquestionnairesurvey
AT inuiayano healthrelatedqualityoflifeinpatientswithautoimmunehepatitisaquestionnairesurvey
AT fujisawatomoo healthrelatedqualityoflifeinpatientswithautoimmunehepatitisaquestionnairesurvey
AT yoshizawakaname healthrelatedqualityoflifeinpatientswithautoimmunehepatitisaquestionnairesurvey
AT suzukiyoshiyuki healthrelatedqualityoflifeinpatientswithautoimmunehepatitisaquestionnairesurvey
AT nakamotonobuhiro healthrelatedqualityoflifeinpatientswithautoimmunehepatitisaquestionnairesurvey
AT koikekazuhiko healthrelatedqualityoflifeinpatientswithautoimmunehepatitisaquestionnairesurvey
AT yoshijihitoshi healthrelatedqualityoflifeinpatientswithautoimmunehepatitisaquestionnairesurvey
AT gotoaya healthrelatedqualityoflifeinpatientswithautoimmunehepatitisaquestionnairesurvey
AT tanakaatsushi healthrelatedqualityoflifeinpatientswithautoimmunehepatitisaquestionnairesurvey
AT younossizobairm healthrelatedqualityoflifeinpatientswithautoimmunehepatitisaquestionnairesurvey
AT takikawahajime healthrelatedqualityoflifeinpatientswithautoimmunehepatitisaquestionnairesurvey
AT healthrelatedqualityoflifeinpatientswithautoimmunehepatitisaquestionnairesurvey