Cargando…
Role of fibroblast growth factor receptor 4 in cancer
Fibroblast growth factor receptors (FGFR) play a significant role in both embryonic development and in adults. Upon binding with ligands, FGFR signaling is activated and triggers various downstream signal cascades that are implicated in diverse biological processes. Aberrant regulations of FGFR sign...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172014/ https://www.ncbi.nlm.nih.gov/pubmed/30070748 http://dx.doi.org/10.1111/cas.13759 |
_version_ | 1783360865433550848 |
---|---|
author | Tang, Shuya Hao, Yilong Yuan, Yao Liu, Rui Chen, Qianming |
author_facet | Tang, Shuya Hao, Yilong Yuan, Yao Liu, Rui Chen, Qianming |
author_sort | Tang, Shuya |
collection | PubMed |
description | Fibroblast growth factor receptors (FGFR) play a significant role in both embryonic development and in adults. Upon binding with ligands, FGFR signaling is activated and triggers various downstream signal cascades that are implicated in diverse biological processes. Aberrant regulations of FGFR signaling are detected in numerous cancers. Although FGFR4 was discovered later than other FGFR, information on the involvement of FGFR4 in cancers has significantly increased in recent years. In this review, the recent findings in FGFR4 structure, signaling transduction, physiological function, aberrant regulations, and effects in cancers as well as its potential applications as an anticancer therapeutic target are summarized. |
format | Online Article Text |
id | pubmed-6172014 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-61720142018-10-10 Role of fibroblast growth factor receptor 4 in cancer Tang, Shuya Hao, Yilong Yuan, Yao Liu, Rui Chen, Qianming Cancer Sci Review Articles Fibroblast growth factor receptors (FGFR) play a significant role in both embryonic development and in adults. Upon binding with ligands, FGFR signaling is activated and triggers various downstream signal cascades that are implicated in diverse biological processes. Aberrant regulations of FGFR signaling are detected in numerous cancers. Although FGFR4 was discovered later than other FGFR, information on the involvement of FGFR4 in cancers has significantly increased in recent years. In this review, the recent findings in FGFR4 structure, signaling transduction, physiological function, aberrant regulations, and effects in cancers as well as its potential applications as an anticancer therapeutic target are summarized. John Wiley and Sons Inc. 2018-10-03 2018-10 /pmc/articles/PMC6172014/ /pubmed/30070748 http://dx.doi.org/10.1111/cas.13759 Text en © 2018 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Review Articles Tang, Shuya Hao, Yilong Yuan, Yao Liu, Rui Chen, Qianming Role of fibroblast growth factor receptor 4 in cancer |
title | Role of fibroblast growth factor receptor 4 in cancer |
title_full | Role of fibroblast growth factor receptor 4 in cancer |
title_fullStr | Role of fibroblast growth factor receptor 4 in cancer |
title_full_unstemmed | Role of fibroblast growth factor receptor 4 in cancer |
title_short | Role of fibroblast growth factor receptor 4 in cancer |
title_sort | role of fibroblast growth factor receptor 4 in cancer |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172014/ https://www.ncbi.nlm.nih.gov/pubmed/30070748 http://dx.doi.org/10.1111/cas.13759 |
work_keys_str_mv | AT tangshuya roleoffibroblastgrowthfactorreceptor4incancer AT haoyilong roleoffibroblastgrowthfactorreceptor4incancer AT yuanyao roleoffibroblastgrowthfactorreceptor4incancer AT liurui roleoffibroblastgrowthfactorreceptor4incancer AT chenqianming roleoffibroblastgrowthfactorreceptor4incancer |