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Enhanced ER proteostasis and temperature differentially impact the mutational tolerance of influenza hemagglutinin

We systematically and quantitatively evaluate whether endoplasmic reticulum (ER) proteostasis factors impact the mutational tolerance of secretory pathway proteins. We focus on influenza hemaggluttinin (HA), a viral membrane protein that folds in the host’s ER via a complex pathway. By integrating c...

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Detalles Bibliográficos
Autores principales:	Phillips, Angela M, Doud, Michael B, Gonzalez, Luna O, Butty, Vincent L, Lin, Yu-Shan, Bloom, Jesse D, Shoulders, Matthew D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172027/ https://www.ncbi.nlm.nih.gov/pubmed/30188321 http://dx.doi.org/10.7554/eLife.38795

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