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Fatty pancreas: A possible risk factor for pancreatic cancer in animals and humans
Obesity, type 2 diabetes mellitus (T2DM) and aging are associated with pancreatic cancer risk, but the mechanisms of pancreatic cancer development caused by these factors are not clearly understood. Syrian golden hamsters are susceptible to N‐nitrosobis(2‐oxopropyl)amine (BOP)‐induced pancreatic car...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172058/ https://www.ncbi.nlm.nih.gov/pubmed/30099827 http://dx.doi.org/10.1111/cas.13766 |
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author | Takahashi, Mami Hori, Mika Ishigamori, Rikako Mutoh, Michihiro Imai, Toshio Nakagama, Hitoshi |
author_facet | Takahashi, Mami Hori, Mika Ishigamori, Rikako Mutoh, Michihiro Imai, Toshio Nakagama, Hitoshi |
author_sort | Takahashi, Mami |
collection | PubMed |
description | Obesity, type 2 diabetes mellitus (T2DM) and aging are associated with pancreatic cancer risk, but the mechanisms of pancreatic cancer development caused by these factors are not clearly understood. Syrian golden hamsters are susceptible to N‐nitrosobis(2‐oxopropyl)amine (BOP)‐induced pancreatic carcinogenesis. Aging, BOP treatment and/or a high‐fat diet cause severe and scattered fatty infiltration (FI) of the pancreas with abnormal adipokine production and promote pancreatic ductal adenocarcinoma (PDAC) development. The KK‐A (y) mouse, a T2DM model, also develops severe and scattered FI of the pancreas. Treatment with BOP induced significantly higher cell proliferation in the pancreatic ducts of KK‐A (y) mice, but not in those of ICR and C57BL/6J mice, both of which are characterized by an absence of scattered FI. Thus, we hypothesized that severely scattered FI may be involved in the susceptibility to PDAC development. Indeed, severe pancreatic FI, or fatty pancreas, is observed in humans and is associated with age, body mass index (BMI) and DM, which are risk factors for pancreatic cancer. We analyzed the degree of FI in the non‐cancerous parts of PDAC and non‐PDAC patients who had undergone pancreatoduodenectomy by histopathology and demonstrated that the degree of pancreatic FI in PDAC cases is significantly higher than that in non‐PDAC controls. Moreover, the association with PDAC is positive, even after adjusting for BMI and the prevalence of DM. Accumulating evidence suggests that pancreatic FI is involved in PDAC development in animals and humans, and further investigations to clarify the genetic and environmental factors that cause pancreatic FI are warranted. |
format | Online Article Text |
id | pubmed-6172058 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-61720582018-10-10 Fatty pancreas: A possible risk factor for pancreatic cancer in animals and humans Takahashi, Mami Hori, Mika Ishigamori, Rikako Mutoh, Michihiro Imai, Toshio Nakagama, Hitoshi Cancer Sci Review Articles Obesity, type 2 diabetes mellitus (T2DM) and aging are associated with pancreatic cancer risk, but the mechanisms of pancreatic cancer development caused by these factors are not clearly understood. Syrian golden hamsters are susceptible to N‐nitrosobis(2‐oxopropyl)amine (BOP)‐induced pancreatic carcinogenesis. Aging, BOP treatment and/or a high‐fat diet cause severe and scattered fatty infiltration (FI) of the pancreas with abnormal adipokine production and promote pancreatic ductal adenocarcinoma (PDAC) development. The KK‐A (y) mouse, a T2DM model, also develops severe and scattered FI of the pancreas. Treatment with BOP induced significantly higher cell proliferation in the pancreatic ducts of KK‐A (y) mice, but not in those of ICR and C57BL/6J mice, both of which are characterized by an absence of scattered FI. Thus, we hypothesized that severely scattered FI may be involved in the susceptibility to PDAC development. Indeed, severe pancreatic FI, or fatty pancreas, is observed in humans and is associated with age, body mass index (BMI) and DM, which are risk factors for pancreatic cancer. We analyzed the degree of FI in the non‐cancerous parts of PDAC and non‐PDAC patients who had undergone pancreatoduodenectomy by histopathology and demonstrated that the degree of pancreatic FI in PDAC cases is significantly higher than that in non‐PDAC controls. Moreover, the association with PDAC is positive, even after adjusting for BMI and the prevalence of DM. Accumulating evidence suggests that pancreatic FI is involved in PDAC development in animals and humans, and further investigations to clarify the genetic and environmental factors that cause pancreatic FI are warranted. John Wiley and Sons Inc. 2018-09-05 2018-10 /pmc/articles/PMC6172058/ /pubmed/30099827 http://dx.doi.org/10.1111/cas.13766 Text en © 2018 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Review Articles Takahashi, Mami Hori, Mika Ishigamori, Rikako Mutoh, Michihiro Imai, Toshio Nakagama, Hitoshi Fatty pancreas: A possible risk factor for pancreatic cancer in animals and humans |
title | Fatty pancreas: A possible risk factor for pancreatic cancer in animals and humans |
title_full | Fatty pancreas: A possible risk factor for pancreatic cancer in animals and humans |
title_fullStr | Fatty pancreas: A possible risk factor for pancreatic cancer in animals and humans |
title_full_unstemmed | Fatty pancreas: A possible risk factor for pancreatic cancer in animals and humans |
title_short | Fatty pancreas: A possible risk factor for pancreatic cancer in animals and humans |
title_sort | fatty pancreas: a possible risk factor for pancreatic cancer in animals and humans |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172058/ https://www.ncbi.nlm.nih.gov/pubmed/30099827 http://dx.doi.org/10.1111/cas.13766 |
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