Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells

Telomere maintenance by telomerase activity supports the infinite growth of cancer cells. MST-312, a synthetic telomerase inhibitor, gradually shortens telomeres at non-acute lethal doses and eventually induces senescence and apoptosis of telomerase-positive cancer cells. Here we report that MST-312...

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Detalles Bibliográficos
Autores principales: Fujiwara, Chiaki, Muramatsu, Yukiko, Nishii, Megumi, Tokunaka, Kazuhiro, Tahara, Hidetoshi, Ueno, Masaru, Yamori, Takao, Sugimoto, Yoshikazu, Seimiya, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172206/
https://www.ncbi.nlm.nih.gov/pubmed/30287851
http://dx.doi.org/10.1038/s41598-018-33139-x

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