Humanization of Antibodies using a Statistical Inference Approach

Antibody humanization is a key step in the preclinical phase of the development of therapeutic antibodies, originally developed and tested in non-human models (most typically, in mouse). The standard technique of Complementarity-Determining Regions (CDR) grafting into human Framework Regions of germ...

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Detalles Bibliográficos
Autores principales: Clavero-Álvarez, Alejandro, Di Mambro, Tomas, Perez-Gaviro, Sergio, Magnani, Mauro, Bruscolini, Pierpaolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172228/
https://www.ncbi.nlm.nih.gov/pubmed/30287940
http://dx.doi.org/10.1038/s41598-018-32986-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172228/
https://www.ncbi.nlm.nih.gov/pubmed/30287940
http://dx.doi.org/10.1038/s41598-018-32986-y

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