Procaspase-3-activating compound 1 stabilizes hypoxia-inducible factor 1α and induces DNA damage by sequestering ferrous iron

Procaspase-3-activating compound 1 (PAC-1) induces procaspase-3 activation via zinc chelation. However, whether PAC-1 employs other mechanisms remains unknown. Here we systematically screened for potent PAC-1 targets using 29 enhanced green fluorescent protein-labeled reporter cell lines and identif...

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Detalles Bibliográficos
Autores principales: Li, Feifei, Wei, Aili, Bu, Lijuan, Long, Long, Chen, Wei, Wang, Chen, Zhao, Changqi, Wang, Lili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172261/
https://www.ncbi.nlm.nih.gov/pubmed/30287840
http://dx.doi.org/10.1038/s41419-018-1038-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172261/
https://www.ncbi.nlm.nih.gov/pubmed/30287840
http://dx.doi.org/10.1038/s41419-018-1038-3

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