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Two-photon polymerisation 3D printed freeform micro-optics for optical coherence tomography fibre probes

Miniaturised optical coherence tomography (OCT) fibre-optic probes have enabled high-resolution cross-sectional imaging deep within the body. However, existing OCT fibre-optic probe fabrication methods cannot generate miniaturised freeform optics, which limits our ability to fabricate probes with bo...

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Autores principales: Li, Jiawen, Fejes, Peter, Lorenser, Dirk, Quirk, Bryden C., Noble, Peter B., Kirk, Rodney W., Orth, Antony, Wood, Fiona M., Gibson, Brant C., Sampson, David D., McLaughlin, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172275/
https://www.ncbi.nlm.nih.gov/pubmed/30287830
http://dx.doi.org/10.1038/s41598-018-32407-0
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author Li, Jiawen
Fejes, Peter
Lorenser, Dirk
Quirk, Bryden C.
Noble, Peter B.
Kirk, Rodney W.
Orth, Antony
Wood, Fiona M.
Gibson, Brant C.
Sampson, David D.
McLaughlin, Robert A.
author_facet Li, Jiawen
Fejes, Peter
Lorenser, Dirk
Quirk, Bryden C.
Noble, Peter B.
Kirk, Rodney W.
Orth, Antony
Wood, Fiona M.
Gibson, Brant C.
Sampson, David D.
McLaughlin, Robert A.
author_sort Li, Jiawen
collection PubMed
description Miniaturised optical coherence tomography (OCT) fibre-optic probes have enabled high-resolution cross-sectional imaging deep within the body. However, existing OCT fibre-optic probe fabrication methods cannot generate miniaturised freeform optics, which limits our ability to fabricate probes with both complex optical function and dimensions comparable to the optical fibre diameter. Recently, major advances in two-photon direct laser writing have enabled 3D printing of arbitrary three-dimensional micro/nanostructures with a surface roughness acceptable for optical applications. Here, we demonstrate the feasibility of 3D printing of OCT probes. We evaluate the capability of this method based on a series of characterisation experiments. We report fabrication of a micro-optic containing an off-axis paraboloidal total internal reflecting surface, its integration as part of a common-path OCT probe, and demonstrate proof-of-principle imaging of biological samples.
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spelling pubmed-61722752018-10-09 Two-photon polymerisation 3D printed freeform micro-optics for optical coherence tomography fibre probes Li, Jiawen Fejes, Peter Lorenser, Dirk Quirk, Bryden C. Noble, Peter B. Kirk, Rodney W. Orth, Antony Wood, Fiona M. Gibson, Brant C. Sampson, David D. McLaughlin, Robert A. Sci Rep Article Miniaturised optical coherence tomography (OCT) fibre-optic probes have enabled high-resolution cross-sectional imaging deep within the body. However, existing OCT fibre-optic probe fabrication methods cannot generate miniaturised freeform optics, which limits our ability to fabricate probes with both complex optical function and dimensions comparable to the optical fibre diameter. Recently, major advances in two-photon direct laser writing have enabled 3D printing of arbitrary three-dimensional micro/nanostructures with a surface roughness acceptable for optical applications. Here, we demonstrate the feasibility of 3D printing of OCT probes. We evaluate the capability of this method based on a series of characterisation experiments. We report fabrication of a micro-optic containing an off-axis paraboloidal total internal reflecting surface, its integration as part of a common-path OCT probe, and demonstrate proof-of-principle imaging of biological samples. Nature Publishing Group UK 2018-10-04 /pmc/articles/PMC6172275/ /pubmed/30287830 http://dx.doi.org/10.1038/s41598-018-32407-0 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Li, Jiawen
Fejes, Peter
Lorenser, Dirk
Quirk, Bryden C.
Noble, Peter B.
Kirk, Rodney W.
Orth, Antony
Wood, Fiona M.
Gibson, Brant C.
Sampson, David D.
McLaughlin, Robert A.
Two-photon polymerisation 3D printed freeform micro-optics for optical coherence tomography fibre probes
title Two-photon polymerisation 3D printed freeform micro-optics for optical coherence tomography fibre probes
title_full Two-photon polymerisation 3D printed freeform micro-optics for optical coherence tomography fibre probes
title_fullStr Two-photon polymerisation 3D printed freeform micro-optics for optical coherence tomography fibre probes
title_full_unstemmed Two-photon polymerisation 3D printed freeform micro-optics for optical coherence tomography fibre probes
title_short Two-photon polymerisation 3D printed freeform micro-optics for optical coherence tomography fibre probes
title_sort two-photon polymerisation 3d printed freeform micro-optics for optical coherence tomography fibre probes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172275/
https://www.ncbi.nlm.nih.gov/pubmed/30287830
http://dx.doi.org/10.1038/s41598-018-32407-0
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