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Genome-wide association study identifies two risk loci for tuberculosis in Han Chinese
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb), and remains a leading public health problem. Previous studies have identified host genetic factors that contribute to Mtb infection outcomes. However, much of the heritability in TB remains unaccounted for and add...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172286/ https://www.ncbi.nlm.nih.gov/pubmed/30287856 http://dx.doi.org/10.1038/s41467-018-06539-w |
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| author | Zheng, Ruijuan Li, Zhiqiang He, Fusheng Liu, Haipeng Chen, Jianhua Chen, Jiayu Xie, Xuefeng Zhou, Juan Chen, Hao Wu, Xiangyang Wu, Juehui Chen, Boyu Liu, Yahui Cui, Haiyan Fan, Lin Sha, Wei Liu, Yin Wang, Jiqiang Huang, Xiaochen Zhang, Linfeng Xu, Feifan Wang, Jie Feng, Yonghong Qin, Lianhua Yang, Hua Liu, Zhonghua Cui, Zhenglin Liu, Feng Chen, Xinchun Gao, Shaorong Sun, Silong Shi, Yongyong Ge, Baoxue |
| author_facet | Zheng, Ruijuan Li, Zhiqiang He, Fusheng Liu, Haipeng Chen, Jianhua Chen, Jiayu Xie, Xuefeng Zhou, Juan Chen, Hao Wu, Xiangyang Wu, Juehui Chen, Boyu Liu, Yahui Cui, Haiyan Fan, Lin Sha, Wei Liu, Yin Wang, Jiqiang Huang, Xiaochen Zhang, Linfeng Xu, Feifan Wang, Jie Feng, Yonghong Qin, Lianhua Yang, Hua Liu, Zhonghua Cui, Zhenglin Liu, Feng Chen, Xinchun Gao, Shaorong Sun, Silong Shi, Yongyong Ge, Baoxue |
| author_sort | Zheng, Ruijuan |
| collection | PubMed |
| description | Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb), and remains a leading public health problem. Previous studies have identified host genetic factors that contribute to Mtb infection outcomes. However, much of the heritability in TB remains unaccounted for and additional susceptibility loci most likely exist. We perform a multistage genome-wide association study on 2949 pulmonary TB patients and 5090 healthy controls (833 cases and 1220 controls were genome-wide genotyped) from Han Chinese population. We discover two risk loci: 14q24.3 (rs12437118, P(combined) = 1.72 × 10(−11), OR = 1.277, ESRRB) and 20p13 (rs6114027, P(combined) = 2.37 × 10(−11), OR = 1.339, TGM6). Moreover, we determine that the rs6114027 risk allele is related to decreased TGM6 transcripts in PBMCs from pulmonary TB patients and severer pulmonary TB disease. Furthermore, we find that tgm6-deficient mice are more susceptible to Mtb infection. Our results provide new insights into the genetic etiology of TB. |
| format | Online Article Text |
| id | pubmed-6172286 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-61722862018-10-09 Genome-wide association study identifies two risk loci for tuberculosis in Han Chinese Zheng, Ruijuan Li, Zhiqiang He, Fusheng Liu, Haipeng Chen, Jianhua Chen, Jiayu Xie, Xuefeng Zhou, Juan Chen, Hao Wu, Xiangyang Wu, Juehui Chen, Boyu Liu, Yahui Cui, Haiyan Fan, Lin Sha, Wei Liu, Yin Wang, Jiqiang Huang, Xiaochen Zhang, Linfeng Xu, Feifan Wang, Jie Feng, Yonghong Qin, Lianhua Yang, Hua Liu, Zhonghua Cui, Zhenglin Liu, Feng Chen, Xinchun Gao, Shaorong Sun, Silong Shi, Yongyong Ge, Baoxue Nat Commun Article Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb), and remains a leading public health problem. Previous studies have identified host genetic factors that contribute to Mtb infection outcomes. However, much of the heritability in TB remains unaccounted for and additional susceptibility loci most likely exist. We perform a multistage genome-wide association study on 2949 pulmonary TB patients and 5090 healthy controls (833 cases and 1220 controls were genome-wide genotyped) from Han Chinese population. We discover two risk loci: 14q24.3 (rs12437118, P(combined) = 1.72 × 10(−11), OR = 1.277, ESRRB) and 20p13 (rs6114027, P(combined) = 2.37 × 10(−11), OR = 1.339, TGM6). Moreover, we determine that the rs6114027 risk allele is related to decreased TGM6 transcripts in PBMCs from pulmonary TB patients and severer pulmonary TB disease. Furthermore, we find that tgm6-deficient mice are more susceptible to Mtb infection. Our results provide new insights into the genetic etiology of TB. Nature Publishing Group UK 2018-10-04 /pmc/articles/PMC6172286/ /pubmed/30287856 http://dx.doi.org/10.1038/s41467-018-06539-w Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Article Zheng, Ruijuan Li, Zhiqiang He, Fusheng Liu, Haipeng Chen, Jianhua Chen, Jiayu Xie, Xuefeng Zhou, Juan Chen, Hao Wu, Xiangyang Wu, Juehui Chen, Boyu Liu, Yahui Cui, Haiyan Fan, Lin Sha, Wei Liu, Yin Wang, Jiqiang Huang, Xiaochen Zhang, Linfeng Xu, Feifan Wang, Jie Feng, Yonghong Qin, Lianhua Yang, Hua Liu, Zhonghua Cui, Zhenglin Liu, Feng Chen, Xinchun Gao, Shaorong Sun, Silong Shi, Yongyong Ge, Baoxue Genome-wide association study identifies two risk loci for tuberculosis in Han Chinese |
| title | Genome-wide association study identifies two risk loci for tuberculosis in Han Chinese |
| title_full | Genome-wide association study identifies two risk loci for tuberculosis in Han Chinese |
| title_fullStr | Genome-wide association study identifies two risk loci for tuberculosis in Han Chinese |
| title_full_unstemmed | Genome-wide association study identifies two risk loci for tuberculosis in Han Chinese |
| title_short | Genome-wide association study identifies two risk loci for tuberculosis in Han Chinese |
| title_sort | genome-wide association study identifies two risk loci for tuberculosis in han chinese |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172286/ https://www.ncbi.nlm.nih.gov/pubmed/30287856 http://dx.doi.org/10.1038/s41467-018-06539-w |
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