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Prognostic influence of 3-dimensional tumor volume on breast cancer compared to conventional 1-dimensional tumor size

PURPOSE: The prognostic influence of 3-dimensional tumor volume (Tv) on breast cancer compared to conventional 1-dimensional tumor size (T) was investigated. METHODS: Analysis was performed on a cohort of 8,996 primary breast cancer patients who were initially diagnosed with TNM stage I–III. Tumor s...

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Autores principales: Hwang, Ki-Tae, Han, Wonshik, Lee, Sang Mok, Choi, Jaewoo, Kim, Jongjin, Rhu, Jiyoung, Kim, Young A, Noh, Dong-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Surgical Society 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172357/
https://www.ncbi.nlm.nih.gov/pubmed/30310801
http://dx.doi.org/10.4174/astr.2018.95.4.183
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author Hwang, Ki-Tae
Han, Wonshik
Lee, Sang Mok
Choi, Jaewoo
Kim, Jongjin
Rhu, Jiyoung
Kim, Young A
Noh, Dong-Young
author_facet Hwang, Ki-Tae
Han, Wonshik
Lee, Sang Mok
Choi, Jaewoo
Kim, Jongjin
Rhu, Jiyoung
Kim, Young A
Noh, Dong-Young
author_sort Hwang, Ki-Tae
collection PubMed
description PURPOSE: The prognostic influence of 3-dimensional tumor volume (Tv) on breast cancer compared to conventional 1-dimensional tumor size (T) was investigated. METHODS: Analysis was performed on a cohort of 8,996 primary breast cancer patients who were initially diagnosed with TNM stage I–III. Tumor size was defined as the maximum tumor dimension, and Tv was calculated by the equation of (4π × r1 × r2 × r3)/3; r1, r2, and r3 were defined as half of the largest, intermediate, and shortest dimension of the tumor, respectively. Tv was classified into Tv1, Tv2, and Tv3 according to the cut off values of 2.056 cm(3) and 20.733 cm(3). RESULTS: The survival curves according to both the T and Tv categories were clearly differentiated (all P < 0.001), as were those for staging by T and Tv (all P < 0.001). In T1 and T2 tumors, the Tv1 group showed superior survival over the Tv2 group (T1, P < 0.001; T2, P = 0.001). Univariate and multivariate analysis both indicated that Tv was a significant prognostic factor (both P < 0.001). The receiver operating characteristic curve showed that the area under the curves were 0.712 (P < 0.001) for Tv and 0.699 (P < 0.001) for T. Positive correlations were observed between the number of positive nodes and T (coefficient = 0.325; P < 0.001), and between the number of positive nodes and Tv (coefficient = 0.321; P < 0.001). CONCLUSION: Tv classification works well for predicting the prognosis of breast cancer, and it is a better predictor than conventional T classification in several aspects. Further studies are needed to validate the practical usefulness of Tv classification in clinical settings.
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spelling pubmed-61723572018-10-11 Prognostic influence of 3-dimensional tumor volume on breast cancer compared to conventional 1-dimensional tumor size Hwang, Ki-Tae Han, Wonshik Lee, Sang Mok Choi, Jaewoo Kim, Jongjin Rhu, Jiyoung Kim, Young A Noh, Dong-Young Ann Surg Treat Res Original Article PURPOSE: The prognostic influence of 3-dimensional tumor volume (Tv) on breast cancer compared to conventional 1-dimensional tumor size (T) was investigated. METHODS: Analysis was performed on a cohort of 8,996 primary breast cancer patients who were initially diagnosed with TNM stage I–III. Tumor size was defined as the maximum tumor dimension, and Tv was calculated by the equation of (4π × r1 × r2 × r3)/3; r1, r2, and r3 were defined as half of the largest, intermediate, and shortest dimension of the tumor, respectively. Tv was classified into Tv1, Tv2, and Tv3 according to the cut off values of 2.056 cm(3) and 20.733 cm(3). RESULTS: The survival curves according to both the T and Tv categories were clearly differentiated (all P < 0.001), as were those for staging by T and Tv (all P < 0.001). In T1 and T2 tumors, the Tv1 group showed superior survival over the Tv2 group (T1, P < 0.001; T2, P = 0.001). Univariate and multivariate analysis both indicated that Tv was a significant prognostic factor (both P < 0.001). The receiver operating characteristic curve showed that the area under the curves were 0.712 (P < 0.001) for Tv and 0.699 (P < 0.001) for T. Positive correlations were observed between the number of positive nodes and T (coefficient = 0.325; P < 0.001), and between the number of positive nodes and Tv (coefficient = 0.321; P < 0.001). CONCLUSION: Tv classification works well for predicting the prognosis of breast cancer, and it is a better predictor than conventional T classification in several aspects. Further studies are needed to validate the practical usefulness of Tv classification in clinical settings. The Korean Surgical Society 2018-10 2018-09-28 /pmc/articles/PMC6172357/ /pubmed/30310801 http://dx.doi.org/10.4174/astr.2018.95.4.183 Text en Copyright © 2018, the Korean Surgical Society http://creativecommons.org/licenses/by-nc/4.0/ Annals of Surgical Treatment and Research is an Open Access Journal. All articles are distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Hwang, Ki-Tae
Han, Wonshik
Lee, Sang Mok
Choi, Jaewoo
Kim, Jongjin
Rhu, Jiyoung
Kim, Young A
Noh, Dong-Young
Prognostic influence of 3-dimensional tumor volume on breast cancer compared to conventional 1-dimensional tumor size
title Prognostic influence of 3-dimensional tumor volume on breast cancer compared to conventional 1-dimensional tumor size
title_full Prognostic influence of 3-dimensional tumor volume on breast cancer compared to conventional 1-dimensional tumor size
title_fullStr Prognostic influence of 3-dimensional tumor volume on breast cancer compared to conventional 1-dimensional tumor size
title_full_unstemmed Prognostic influence of 3-dimensional tumor volume on breast cancer compared to conventional 1-dimensional tumor size
title_short Prognostic influence of 3-dimensional tumor volume on breast cancer compared to conventional 1-dimensional tumor size
title_sort prognostic influence of 3-dimensional tumor volume on breast cancer compared to conventional 1-dimensional tumor size
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172357/
https://www.ncbi.nlm.nih.gov/pubmed/30310801
http://dx.doi.org/10.4174/astr.2018.95.4.183
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