Modeling Hematological Diseases and Cancer With Patient-Specific Induced Pluripotent Stem Cells

The advent of induced pluripotent stem cells (iPSCs) together with recent advances in genome editing, microphysiological systems, tissue engineering and xenograft models present new opportunities for the investigation of hematological diseases and cancer in a patient-specific context. Here we review...

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Detalles Bibliográficos
Autores principales: Kim, Huensuk, Schaniel, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172418/
https://www.ncbi.nlm.nih.gov/pubmed/30323816
http://dx.doi.org/10.3389/fimmu.2018.02243
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author Kim, Huensuk
Schaniel, Christoph
author_facet Kim, Huensuk
Schaniel, Christoph
author_sort Kim, Huensuk
collection PubMed
description The advent of induced pluripotent stem cells (iPSCs) together with recent advances in genome editing, microphysiological systems, tissue engineering and xenograft models present new opportunities for the investigation of hematological diseases and cancer in a patient-specific context. Here we review the progress in the field and discuss the advantages, limitations, and challenges of iPSC-based malignancy modeling. We will also discuss the use of iPSCs and its derivatives as cellular sources for drug target identification, drug development and evaluation of pharmacological responses.
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spelling pubmed-61724182018-10-15 Modeling Hematological Diseases and Cancer With Patient-Specific Induced Pluripotent Stem Cells Kim, Huensuk Schaniel, Christoph Front Immunol Immunology The advent of induced pluripotent stem cells (iPSCs) together with recent advances in genome editing, microphysiological systems, tissue engineering and xenograft models present new opportunities for the investigation of hematological diseases and cancer in a patient-specific context. Here we review the progress in the field and discuss the advantages, limitations, and challenges of iPSC-based malignancy modeling. We will also discuss the use of iPSCs and its derivatives as cellular sources for drug target identification, drug development and evaluation of pharmacological responses. Frontiers Media S.A. 2018-09-28 /pmc/articles/PMC6172418/ /pubmed/30323816 http://dx.doi.org/10.3389/fimmu.2018.02243 Text en Copyright © 2018 Kim and Schaniel. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Kim, Huensuk
Schaniel, Christoph
Modeling Hematological Diseases and Cancer With Patient-Specific Induced Pluripotent Stem Cells
title Modeling Hematological Diseases and Cancer With Patient-Specific Induced Pluripotent Stem Cells
title_full Modeling Hematological Diseases and Cancer With Patient-Specific Induced Pluripotent Stem Cells
title_fullStr Modeling Hematological Diseases and Cancer With Patient-Specific Induced Pluripotent Stem Cells
title_full_unstemmed Modeling Hematological Diseases and Cancer With Patient-Specific Induced Pluripotent Stem Cells
title_short Modeling Hematological Diseases and Cancer With Patient-Specific Induced Pluripotent Stem Cells
title_sort modeling hematological diseases and cancer with patient-specific induced pluripotent stem cells
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172418/
https://www.ncbi.nlm.nih.gov/pubmed/30323816
http://dx.doi.org/10.3389/fimmu.2018.02243
work_keys_str_mv AT kimhuensuk modelinghematologicaldiseasesandcancerwithpatientspecificinducedpluripotentstemcells
AT schanielchristoph modelinghematologicaldiseasesandcancerwithpatientspecificinducedpluripotentstemcells

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