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Oligonucleotide Aptamer-Mediated Precision Therapy of Hematological Malignancies
Precision medicine has recently emerged as a promising strategy for cancer therapy because it not only specifically targets cancer cells but it also does not have adverse effects on normal cells. Oligonucleotide aptamers are a class of small molecule ligands that can specifically bind to their targe...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Gene & Cell Therapy
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172475/ https://www.ncbi.nlm.nih.gov/pubmed/30292138 http://dx.doi.org/10.1016/j.omtn.2018.08.023 |
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author | Yang, Shuanghui Li, Huan Xu, Ling Deng, Zhenhan Han, Wei Liu, Yanting Jiang, Wenqi Zu, Youli |
author_facet | Yang, Shuanghui Li, Huan Xu, Ling Deng, Zhenhan Han, Wei Liu, Yanting Jiang, Wenqi Zu, Youli |
author_sort | Yang, Shuanghui |
collection | PubMed |
description | Precision medicine has recently emerged as a promising strategy for cancer therapy because it not only specifically targets cancer cells but it also does not have adverse effects on normal cells. Oligonucleotide aptamers are a class of small molecule ligands that can specifically bind to their targets on cell surfaces with high affinity. Aptamers have great potential in precision cancer therapy due to their unique physical, chemical, and biological properties. Therefore, aptamer technology has been widely investigated for biomedical and clinical applications. This review focuses on the potential applications of aptamer technology as a new tool for precision treatment of hematological malignancies, including leukemia, lymphoma, and multiple myeloma. |
format | Online Article Text |
id | pubmed-6172475 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | American Society of Gene & Cell Therapy |
record_format | MEDLINE/PubMed |
spelling | pubmed-61724752018-10-10 Oligonucleotide Aptamer-Mediated Precision Therapy of Hematological Malignancies Yang, Shuanghui Li, Huan Xu, Ling Deng, Zhenhan Han, Wei Liu, Yanting Jiang, Wenqi Zu, Youli Mol Ther Nucleic Acids Article Precision medicine has recently emerged as a promising strategy for cancer therapy because it not only specifically targets cancer cells but it also does not have adverse effects on normal cells. Oligonucleotide aptamers are a class of small molecule ligands that can specifically bind to their targets on cell surfaces with high affinity. Aptamers have great potential in precision cancer therapy due to their unique physical, chemical, and biological properties. Therefore, aptamer technology has been widely investigated for biomedical and clinical applications. This review focuses on the potential applications of aptamer technology as a new tool for precision treatment of hematological malignancies, including leukemia, lymphoma, and multiple myeloma. American Society of Gene & Cell Therapy 2018-09-06 /pmc/articles/PMC6172475/ /pubmed/30292138 http://dx.doi.org/10.1016/j.omtn.2018.08.023 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Yang, Shuanghui Li, Huan Xu, Ling Deng, Zhenhan Han, Wei Liu, Yanting Jiang, Wenqi Zu, Youli Oligonucleotide Aptamer-Mediated Precision Therapy of Hematological Malignancies |
title | Oligonucleotide Aptamer-Mediated Precision Therapy of Hematological Malignancies |
title_full | Oligonucleotide Aptamer-Mediated Precision Therapy of Hematological Malignancies |
title_fullStr | Oligonucleotide Aptamer-Mediated Precision Therapy of Hematological Malignancies |
title_full_unstemmed | Oligonucleotide Aptamer-Mediated Precision Therapy of Hematological Malignancies |
title_short | Oligonucleotide Aptamer-Mediated Precision Therapy of Hematological Malignancies |
title_sort | oligonucleotide aptamer-mediated precision therapy of hematological malignancies |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172475/ https://www.ncbi.nlm.nih.gov/pubmed/30292138 http://dx.doi.org/10.1016/j.omtn.2018.08.023 |
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