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Oligonucleotide Aptamer-Mediated Precision Therapy of Hematological Malignancies

Precision medicine has recently emerged as a promising strategy for cancer therapy because it not only specifically targets cancer cells but it also does not have adverse effects on normal cells. Oligonucleotide aptamers are a class of small molecule ligands that can specifically bind to their targe...

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Detalles Bibliográficos
Autores principales: Yang, Shuanghui, Li, Huan, Xu, Ling, Deng, Zhenhan, Han, Wei, Liu, Yanting, Jiang, Wenqi, Zu, Youli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172475/
https://www.ncbi.nlm.nih.gov/pubmed/30292138
http://dx.doi.org/10.1016/j.omtn.2018.08.023
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author Yang, Shuanghui
Li, Huan
Xu, Ling
Deng, Zhenhan
Han, Wei
Liu, Yanting
Jiang, Wenqi
Zu, Youli
author_facet Yang, Shuanghui
Li, Huan
Xu, Ling
Deng, Zhenhan
Han, Wei
Liu, Yanting
Jiang, Wenqi
Zu, Youli
author_sort Yang, Shuanghui
collection PubMed
description Precision medicine has recently emerged as a promising strategy for cancer therapy because it not only specifically targets cancer cells but it also does not have adverse effects on normal cells. Oligonucleotide aptamers are a class of small molecule ligands that can specifically bind to their targets on cell surfaces with high affinity. Aptamers have great potential in precision cancer therapy due to their unique physical, chemical, and biological properties. Therefore, aptamer technology has been widely investigated for biomedical and clinical applications. This review focuses on the potential applications of aptamer technology as a new tool for precision treatment of hematological malignancies, including leukemia, lymphoma, and multiple myeloma.
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spelling pubmed-61724752018-10-10 Oligonucleotide Aptamer-Mediated Precision Therapy of Hematological Malignancies Yang, Shuanghui Li, Huan Xu, Ling Deng, Zhenhan Han, Wei Liu, Yanting Jiang, Wenqi Zu, Youli Mol Ther Nucleic Acids Article Precision medicine has recently emerged as a promising strategy for cancer therapy because it not only specifically targets cancer cells but it also does not have adverse effects on normal cells. Oligonucleotide aptamers are a class of small molecule ligands that can specifically bind to their targets on cell surfaces with high affinity. Aptamers have great potential in precision cancer therapy due to their unique physical, chemical, and biological properties. Therefore, aptamer technology has been widely investigated for biomedical and clinical applications. This review focuses on the potential applications of aptamer technology as a new tool for precision treatment of hematological malignancies, including leukemia, lymphoma, and multiple myeloma. American Society of Gene & Cell Therapy 2018-09-06 /pmc/articles/PMC6172475/ /pubmed/30292138 http://dx.doi.org/10.1016/j.omtn.2018.08.023 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yang, Shuanghui
Li, Huan
Xu, Ling
Deng, Zhenhan
Han, Wei
Liu, Yanting
Jiang, Wenqi
Zu, Youli
Oligonucleotide Aptamer-Mediated Precision Therapy of Hematological Malignancies
title Oligonucleotide Aptamer-Mediated Precision Therapy of Hematological Malignancies
title_full Oligonucleotide Aptamer-Mediated Precision Therapy of Hematological Malignancies
title_fullStr Oligonucleotide Aptamer-Mediated Precision Therapy of Hematological Malignancies
title_full_unstemmed Oligonucleotide Aptamer-Mediated Precision Therapy of Hematological Malignancies
title_short Oligonucleotide Aptamer-Mediated Precision Therapy of Hematological Malignancies
title_sort oligonucleotide aptamer-mediated precision therapy of hematological malignancies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172475/
https://www.ncbi.nlm.nih.gov/pubmed/30292138
http://dx.doi.org/10.1016/j.omtn.2018.08.023
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