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Primary Oral Mucormycosis Due to Rhizopus microsporus after Allogeneic Stem Cell Transplantation

We herein report a rare case of oral mucormycosis following allogeneic hematopoietic stem cell transplantation. Oral mucormycosis due to Rhizopus microsporus manifested as localized left buccal mucositis with a 1-cm black focus before neutrophil recovery. Combination therapy with liposomal amphoteri...

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Detalles Bibliográficos
Autores principales: Sakamoto, Hikaru, Itonaga, Hidehiro, Sawayama, Yasushi, Taguchi, Jun, Saijo, Tomomi, Kuwatsuka, Sayaka, Hashisako, Mikiko, Kinoshita, Naoe, Oishi, Masao, Doi, Hanako, Kosai, Kosuke, Nishimoto, Katsutaro, Tanaka, Katsumi, Yanagihara, Katsunori, Mukae, Hiroshi, Izumikawa, Koichi, Miyazaki, Yasushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172532/
https://www.ncbi.nlm.nih.gov/pubmed/30175728
http://dx.doi.org/10.2169/internalmedicine.0474-17
Descripción
Sumario:We herein report a rare case of oral mucormycosis following allogeneic hematopoietic stem cell transplantation. Oral mucormycosis due to Rhizopus microsporus manifested as localized left buccal mucositis with a 1-cm black focus before neutrophil recovery. Combination therapy with liposomal amphotericin B was initiated and surgical debridement was performed; however, the patient died due to progressive generalized mucormycosis. Considerable attention needs to be paid to the diagnosis and management of oral mucormycosis in post-transplant patients, thereby suggesting the importance of fully understanding the risk factors.