A Patient with HCV Infection and a Sustained Virological Response to Direct-acting Antiviral Treatment Who Developed Inclusion Body Myositis

We report the case of a 75-year-old woman who was found to have hepatitis C virus (HCV) infection in 1987. Before treatment in 2016, she was found to have mixed cryoglobulinemia (MC). Direct-acting antiviral (DAA) treatment produced a sustained virological response 12 (SVR12). She noticed gradual mu...

Descripción completa

Detalles Bibliográficos
Autores principales: Kuwano, Toru, Akuta, Norio, Suzuki, Fumitaka, Fujiyama, Shunichiro, Kawamura, Yusuke, Sezaki, Hitomi, Hosaka, Tetsuya, Saitoh, Satoshi, Kobayashi, Masahiro, Suzuki, Yoshiyuki, Kobayashi, Mariko, Arase, Yasuji, Ikeda, Kenji, Kumada, Hiromitsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172544/
https://www.ncbi.nlm.nih.gov/pubmed/29607961
http://dx.doi.org/10.2169/internalmedicine.0585-17
_version_ 1783360969981820928
author Kuwano, Toru
Akuta, Norio
Suzuki, Fumitaka
Fujiyama, Shunichiro
Kawamura, Yusuke
Sezaki, Hitomi
Hosaka, Tetsuya
Saitoh, Satoshi
Kobayashi, Masahiro
Suzuki, Yoshiyuki
Kobayashi, Mariko
Arase, Yasuji
Ikeda, Kenji
Kumada, Hiromitsu
author_facet Kuwano, Toru
Akuta, Norio
Suzuki, Fumitaka
Fujiyama, Shunichiro
Kawamura, Yusuke
Sezaki, Hitomi
Hosaka, Tetsuya
Saitoh, Satoshi
Kobayashi, Masahiro
Suzuki, Yoshiyuki
Kobayashi, Mariko
Arase, Yasuji
Ikeda, Kenji
Kumada, Hiromitsu
author_sort Kuwano, Toru
collection PubMed
description We report the case of a 75-year-old woman who was found to have hepatitis C virus (HCV) infection in 1987. Before treatment in 2016, she was found to have mixed cryoglobulinemia (MC). Direct-acting antiviral (DAA) treatment produced a sustained virological response 12 (SVR12). She noticed gradual muscle weakness in 2015 and the gradual development of dysarthria and dysphagia in 2017. We performed a muscle biopsy that showed inclusion body myositis (IBM). To the best of our knowledge, this is first case of a patient with HCV infection, MC, and IBM, in which MC and IBM did not improve after an SVR12 was obtained by DAA treatment.
format Online
Article
Text
id pubmed-6172544
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher The Japanese Society of Internal Medicine
record_format MEDLINE/PubMed
spelling pubmed-61725442018-10-09 A Patient with HCV Infection and a Sustained Virological Response to Direct-acting Antiviral Treatment Who Developed Inclusion Body Myositis Kuwano, Toru Akuta, Norio Suzuki, Fumitaka Fujiyama, Shunichiro Kawamura, Yusuke Sezaki, Hitomi Hosaka, Tetsuya Saitoh, Satoshi Kobayashi, Masahiro Suzuki, Yoshiyuki Kobayashi, Mariko Arase, Yasuji Ikeda, Kenji Kumada, Hiromitsu Intern Med Case Report We report the case of a 75-year-old woman who was found to have hepatitis C virus (HCV) infection in 1987. Before treatment in 2016, she was found to have mixed cryoglobulinemia (MC). Direct-acting antiviral (DAA) treatment produced a sustained virological response 12 (SVR12). She noticed gradual muscle weakness in 2015 and the gradual development of dysarthria and dysphagia in 2017. We performed a muscle biopsy that showed inclusion body myositis (IBM). To the best of our knowledge, this is first case of a patient with HCV infection, MC, and IBM, in which MC and IBM did not improve after an SVR12 was obtained by DAA treatment. The Japanese Society of Internal Medicine 2018-03-30 2018-09-01 /pmc/articles/PMC6172544/ /pubmed/29607961 http://dx.doi.org/10.2169/internalmedicine.0585-17 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kuwano, Toru
Akuta, Norio
Suzuki, Fumitaka
Fujiyama, Shunichiro
Kawamura, Yusuke
Sezaki, Hitomi
Hosaka, Tetsuya
Saitoh, Satoshi
Kobayashi, Masahiro
Suzuki, Yoshiyuki
Kobayashi, Mariko
Arase, Yasuji
Ikeda, Kenji
Kumada, Hiromitsu
A Patient with HCV Infection and a Sustained Virological Response to Direct-acting Antiviral Treatment Who Developed Inclusion Body Myositis
title A Patient with HCV Infection and a Sustained Virological Response to Direct-acting Antiviral Treatment Who Developed Inclusion Body Myositis
title_full A Patient with HCV Infection and a Sustained Virological Response to Direct-acting Antiviral Treatment Who Developed Inclusion Body Myositis
title_fullStr A Patient with HCV Infection and a Sustained Virological Response to Direct-acting Antiviral Treatment Who Developed Inclusion Body Myositis
title_full_unstemmed A Patient with HCV Infection and a Sustained Virological Response to Direct-acting Antiviral Treatment Who Developed Inclusion Body Myositis
title_short A Patient with HCV Infection and a Sustained Virological Response to Direct-acting Antiviral Treatment Who Developed Inclusion Body Myositis
title_sort patient with hcv infection and a sustained virological response to direct-acting antiviral treatment who developed inclusion body myositis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172544/
https://www.ncbi.nlm.nih.gov/pubmed/29607961
http://dx.doi.org/10.2169/internalmedicine.0585-17
work_keys_str_mv AT kuwanotoru apatientwithhcvinfectionandasustainedvirologicalresponsetodirectactingantiviraltreatmentwhodevelopedinclusionbodymyositis
AT akutanorio apatientwithhcvinfectionandasustainedvirologicalresponsetodirectactingantiviraltreatmentwhodevelopedinclusionbodymyositis
AT suzukifumitaka apatientwithhcvinfectionandasustainedvirologicalresponsetodirectactingantiviraltreatmentwhodevelopedinclusionbodymyositis
AT fujiyamashunichiro apatientwithhcvinfectionandasustainedvirologicalresponsetodirectactingantiviraltreatmentwhodevelopedinclusionbodymyositis
AT kawamurayusuke apatientwithhcvinfectionandasustainedvirologicalresponsetodirectactingantiviraltreatmentwhodevelopedinclusionbodymyositis
AT sezakihitomi apatientwithhcvinfectionandasustainedvirologicalresponsetodirectactingantiviraltreatmentwhodevelopedinclusionbodymyositis
AT hosakatetsuya apatientwithhcvinfectionandasustainedvirologicalresponsetodirectactingantiviraltreatmentwhodevelopedinclusionbodymyositis
AT saitohsatoshi apatientwithhcvinfectionandasustainedvirologicalresponsetodirectactingantiviraltreatmentwhodevelopedinclusionbodymyositis
AT kobayashimasahiro apatientwithhcvinfectionandasustainedvirologicalresponsetodirectactingantiviraltreatmentwhodevelopedinclusionbodymyositis
AT suzukiyoshiyuki apatientwithhcvinfectionandasustainedvirologicalresponsetodirectactingantiviraltreatmentwhodevelopedinclusionbodymyositis
AT kobayashimariko apatientwithhcvinfectionandasustainedvirologicalresponsetodirectactingantiviraltreatmentwhodevelopedinclusionbodymyositis
AT araseyasuji apatientwithhcvinfectionandasustainedvirologicalresponsetodirectactingantiviraltreatmentwhodevelopedinclusionbodymyositis
AT ikedakenji apatientwithhcvinfectionandasustainedvirologicalresponsetodirectactingantiviraltreatmentwhodevelopedinclusionbodymyositis
AT kumadahiromitsu apatientwithhcvinfectionandasustainedvirologicalresponsetodirectactingantiviraltreatmentwhodevelopedinclusionbodymyositis
AT kuwanotoru patientwithhcvinfectionandasustainedvirologicalresponsetodirectactingantiviraltreatmentwhodevelopedinclusionbodymyositis
AT akutanorio patientwithhcvinfectionandasustainedvirologicalresponsetodirectactingantiviraltreatmentwhodevelopedinclusionbodymyositis
AT suzukifumitaka patientwithhcvinfectionandasustainedvirologicalresponsetodirectactingantiviraltreatmentwhodevelopedinclusionbodymyositis
AT fujiyamashunichiro patientwithhcvinfectionandasustainedvirologicalresponsetodirectactingantiviraltreatmentwhodevelopedinclusionbodymyositis
AT kawamurayusuke patientwithhcvinfectionandasustainedvirologicalresponsetodirectactingantiviraltreatmentwhodevelopedinclusionbodymyositis
AT sezakihitomi patientwithhcvinfectionandasustainedvirologicalresponsetodirectactingantiviraltreatmentwhodevelopedinclusionbodymyositis
AT hosakatetsuya patientwithhcvinfectionandasustainedvirologicalresponsetodirectactingantiviraltreatmentwhodevelopedinclusionbodymyositis
AT saitohsatoshi patientwithhcvinfectionandasustainedvirologicalresponsetodirectactingantiviraltreatmentwhodevelopedinclusionbodymyositis
AT kobayashimasahiro patientwithhcvinfectionandasustainedvirologicalresponsetodirectactingantiviraltreatmentwhodevelopedinclusionbodymyositis
AT suzukiyoshiyuki patientwithhcvinfectionandasustainedvirologicalresponsetodirectactingantiviraltreatmentwhodevelopedinclusionbodymyositis
AT kobayashimariko patientwithhcvinfectionandasustainedvirologicalresponsetodirectactingantiviraltreatmentwhodevelopedinclusionbodymyositis
AT araseyasuji patientwithhcvinfectionandasustainedvirologicalresponsetodirectactingantiviraltreatmentwhodevelopedinclusionbodymyositis
AT ikedakenji patientwithhcvinfectionandasustainedvirologicalresponsetodirectactingantiviraltreatmentwhodevelopedinclusionbodymyositis
AT kumadahiromitsu patientwithhcvinfectionandasustainedvirologicalresponsetodirectactingantiviraltreatmentwhodevelopedinclusionbodymyositis

Ejemplares similares