The Effect of Everolimus on Refractory Hypoglycemia in a Patient with Inoperable Metastatic Insulinoma Evaluated by Continuous Glucose Monitoring

An 84-year-old Japanese woman with metastatic insulinoma suffered from frequent hypoglycemic events. Continuous glucose monitoring (CGM) confirmed severe and frequent symptomatic/asymptomatic hypoglycemia. After the initiation of everolimus treatment, the hypoglycemic events were rapidly eliminated....

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Autores principales: Yanagiya, Shingo, Cho, Kyu Yong, Nakamura, Akinobu, Nomoto, Hiroshi, Kawamoto, Yasuyuki, Kawakubo, Kazumichi, Komatsu, Yoshito, Mitsuhashi, Tomoko, Miyoshi, Hideaki, Atsumi, Tatsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172558/
https://www.ncbi.nlm.nih.gov/pubmed/29877259
http://dx.doi.org/10.2169/internalmedicine.0126-17
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author Yanagiya, Shingo
Cho, Kyu Yong
Nakamura, Akinobu
Nomoto, Hiroshi
Kawamoto, Yasuyuki
Kawakubo, Kazumichi
Komatsu, Yoshito
Mitsuhashi, Tomoko
Miyoshi, Hideaki
Atsumi, Tatsuya
author_facet Yanagiya, Shingo
Cho, Kyu Yong
Nakamura, Akinobu
Nomoto, Hiroshi
Kawamoto, Yasuyuki
Kawakubo, Kazumichi
Komatsu, Yoshito
Mitsuhashi, Tomoko
Miyoshi, Hideaki
Atsumi, Tatsuya
author_sort Yanagiya, Shingo
collection PubMed
description An 84-year-old Japanese woman with metastatic insulinoma suffered from frequent hypoglycemic events. Continuous glucose monitoring (CGM) confirmed severe and frequent symptomatic/asymptomatic hypoglycemia. After the initiation of everolimus treatment, the hypoglycemic events were rapidly eliminated. CGM revealed that her blood glucose levels were maintained without hypoglycemia throughout the day. Furthermore, everolimus reduced the duration of time above the upper limit (>180 mg/dL) along with the standard deviation and mean amplitude of glycemic excursions. This case shows the potential effects of everolimus on hypoglycemia and glycemic control in a patient with inoperable metastatic insulinoma evaluated by CGM.
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spelling pubmed-61725582018-10-09 The Effect of Everolimus on Refractory Hypoglycemia in a Patient with Inoperable Metastatic Insulinoma Evaluated by Continuous Glucose Monitoring Yanagiya, Shingo Cho, Kyu Yong Nakamura, Akinobu Nomoto, Hiroshi Kawamoto, Yasuyuki Kawakubo, Kazumichi Komatsu, Yoshito Mitsuhashi, Tomoko Miyoshi, Hideaki Atsumi, Tatsuya Intern Med Case Report An 84-year-old Japanese woman with metastatic insulinoma suffered from frequent hypoglycemic events. Continuous glucose monitoring (CGM) confirmed severe and frequent symptomatic/asymptomatic hypoglycemia. After the initiation of everolimus treatment, the hypoglycemic events were rapidly eliminated. CGM revealed that her blood glucose levels were maintained without hypoglycemia throughout the day. Furthermore, everolimus reduced the duration of time above the upper limit (>180 mg/dL) along with the standard deviation and mean amplitude of glycemic excursions. This case shows the potential effects of everolimus on hypoglycemia and glycemic control in a patient with inoperable metastatic insulinoma evaluated by CGM. The Japanese Society of Internal Medicine 2018-06-06 2018-09-01 /pmc/articles/PMC6172558/ /pubmed/29877259 http://dx.doi.org/10.2169/internalmedicine.0126-17 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Yanagiya, Shingo
Cho, Kyu Yong
Nakamura, Akinobu
Nomoto, Hiroshi
Kawamoto, Yasuyuki
Kawakubo, Kazumichi
Komatsu, Yoshito
Mitsuhashi, Tomoko
Miyoshi, Hideaki
Atsumi, Tatsuya
The Effect of Everolimus on Refractory Hypoglycemia in a Patient with Inoperable Metastatic Insulinoma Evaluated by Continuous Glucose Monitoring
title The Effect of Everolimus on Refractory Hypoglycemia in a Patient with Inoperable Metastatic Insulinoma Evaluated by Continuous Glucose Monitoring
title_full The Effect of Everolimus on Refractory Hypoglycemia in a Patient with Inoperable Metastatic Insulinoma Evaluated by Continuous Glucose Monitoring
title_fullStr The Effect of Everolimus on Refractory Hypoglycemia in a Patient with Inoperable Metastatic Insulinoma Evaluated by Continuous Glucose Monitoring
title_full_unstemmed The Effect of Everolimus on Refractory Hypoglycemia in a Patient with Inoperable Metastatic Insulinoma Evaluated by Continuous Glucose Monitoring
title_short The Effect of Everolimus on Refractory Hypoglycemia in a Patient with Inoperable Metastatic Insulinoma Evaluated by Continuous Glucose Monitoring
title_sort effect of everolimus on refractory hypoglycemia in a patient with inoperable metastatic insulinoma evaluated by continuous glucose monitoring
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172558/
https://www.ncbi.nlm.nih.gov/pubmed/29877259
http://dx.doi.org/10.2169/internalmedicine.0126-17
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