Allergic Bronchopulmonary Mycosis Due to Schizophyllum commune Treated Effectively with Voriconazole

A 63-year-old woman presented to our hospital for cough, sputum, and abnormal shadows on chest X-ray. Schizophyllum commune was isolated from mucous plugs. Positive specific IgE and IgG against the fungi, elevated serum IgE, and mucous plugs with typical histologic findings of allergic bronchopulmon...

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Detalles Bibliográficos
Autores principales: Ishiguro, Takashi, Kagiyama, Naho, Kojima, Ayako, Yamada, Masami, Nakamoto, Yasuo, Takaku, Yotaro, Shimizu, Yoshihiko, Kurashima, Kazuyoshi, Takayanagi, Noboru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172560/
https://www.ncbi.nlm.nih.gov/pubmed/29607966
http://dx.doi.org/10.2169/internalmedicine.0668-17
Descripción
Sumario:A 63-year-old woman presented to our hospital for cough, sputum, and abnormal shadows on chest X-ray. Schizophyllum commune was isolated from mucous plugs. Positive specific IgE and IgG against the fungi, elevated serum IgE, and mucous plugs with typical histologic findings of allergic bronchopulmonary mycosis (ABPM) led to the diagnosis of ABPM due to S. commune. We initially administered itraconazole unsuccessfully. Changing the antifungal agent to voriconazole resulted in improvement of the symptoms and chest imaging findings. Her ABPM has not relapsed for two years since the cessation of voriconazole, which was administered for one year.

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