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Synthesis and Biological Evaluation of New Madecassic Acid Derivatives Targeting ERK Cascade Signaling

In the present study, a series of novel madecassic acid derivatives was synthesized and screened against the National Cancer Institute's 60 human cancer cell line panel. Among them, compounds 5, 12, and 17 displayed potent and highly differential antiproliferative activity against 80% of the tu...

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Detalles Bibliográficos
Autores principales:	Valdeira, Ana S. C., Ritt, Daniel A., Morrison, Deborah K., McMahon, James B., Gustafson, Kirk R., Salvador, Jorge A. R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172662/ https://www.ncbi.nlm.nih.gov/pubmed/30324102 http://dx.doi.org/10.3389/fchem.2018.00434

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