The Role of Long Noncoding RNAs in Central Nervous System and Neurodegenerative Diseases

Long noncoding RNAs (lncRNAs) refer to a group of noncoding RNAs (ncRNAs) that has a transcript of more than 200 nucleotides in length in eukaryotic cells. The lncRNAs regulate gene expression at epigenetic, transcriptional, and post-transcriptional levels by multiple action modes. In this review, w...

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Autores principales: Wei, Chang-Wei, Luo, Ting, Zou, Shan-Shan, Wu, An-Shi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Behavioral Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172704/
https://www.ncbi.nlm.nih.gov/pubmed/30323747
http://dx.doi.org/10.3389/fnbeh.2018.00175
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author Wei, Chang-Wei
Luo, Ting
Zou, Shan-Shan
Wu, An-Shi
author_facet Wei, Chang-Wei
Luo, Ting
Zou, Shan-Shan
Wu, An-Shi
author_sort Wei, Chang-Wei
collection PubMed
description Long noncoding RNAs (lncRNAs) refer to a group of noncoding RNAs (ncRNAs) that has a transcript of more than 200 nucleotides in length in eukaryotic cells. The lncRNAs regulate gene expression at epigenetic, transcriptional, and post-transcriptional levels by multiple action modes. In this review, we describe the diverse roles reported for lncRNAs, and discuss how they could mechanistically be involved in the development of central nervous system (CNS) and neurodegenerative diseases. Further studies on the function of lncRNAs and their mechanism will help deepen our understanding of the development, function, and diseases of the CNS, and provide new ideas for the design and development of some therapeutic drugs.
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spelling pubmed-61727042018-10-15 The Role of Long Noncoding RNAs in Central Nervous System and Neurodegenerative Diseases Wei, Chang-Wei Luo, Ting Zou, Shan-Shan Wu, An-Shi Front Behav Neurosci Behavioral Neuroscience Long noncoding RNAs (lncRNAs) refer to a group of noncoding RNAs (ncRNAs) that has a transcript of more than 200 nucleotides in length in eukaryotic cells. The lncRNAs regulate gene expression at epigenetic, transcriptional, and post-transcriptional levels by multiple action modes. In this review, we describe the diverse roles reported for lncRNAs, and discuss how they could mechanistically be involved in the development of central nervous system (CNS) and neurodegenerative diseases. Further studies on the function of lncRNAs and their mechanism will help deepen our understanding of the development, function, and diseases of the CNS, and provide new ideas for the design and development of some therapeutic drugs. Frontiers Media S.A. 2018-09-28 /pmc/articles/PMC6172704/ /pubmed/30323747 http://dx.doi.org/10.3389/fnbeh.2018.00175 Text en Copyright © 2018 Wei, Luo, Zou and Wu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Behavioral Neuroscience
Wei, Chang-Wei
Luo, Ting
Zou, Shan-Shan
Wu, An-Shi
The Role of Long Noncoding RNAs in Central Nervous System and Neurodegenerative Diseases
title The Role of Long Noncoding RNAs in Central Nervous System and Neurodegenerative Diseases
title_full The Role of Long Noncoding RNAs in Central Nervous System and Neurodegenerative Diseases
title_fullStr The Role of Long Noncoding RNAs in Central Nervous System and Neurodegenerative Diseases
title_full_unstemmed The Role of Long Noncoding RNAs in Central Nervous System and Neurodegenerative Diseases
title_short The Role of Long Noncoding RNAs in Central Nervous System and Neurodegenerative Diseases
title_sort role of long noncoding rnas in central nervous system and neurodegenerative diseases
topic Behavioral Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172704/
https://www.ncbi.nlm.nih.gov/pubmed/30323747
http://dx.doi.org/10.3389/fnbeh.2018.00175
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