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Deep proteomic network analysis of Alzheimer’s disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease

BACKGROUND: The complicated cellular and biochemical changes that occur in brain during Alzheimer’s disease are poorly understood. In a previous study we used an unbiased label-free quantitative mass spectrometry-based proteomic approach to analyze these changes at a systems level in post-mortem cor...

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Detalles Bibliográficos
Autores principales:	Johnson, Erik C. B., Dammer, Eric B., Duong, Duc M., Yin, Luming, Thambisetty, Madhav, Troncoso, Juan C., Lah, James J., Levey, Allan I., Seyfried, Nicholas T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172707/ https://www.ncbi.nlm.nih.gov/pubmed/30286791 http://dx.doi.org/10.1186/s13024-018-0282-4

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